Vitamin D as a predictor of clinical response among patients with cardiac resynchronization therapy (CRT)
Issued Date
2024-01-01
Resource Type
ISSN
18804276
eISSN
18832148
Scopus ID
2-s2.0-85198729373
Journal Title
Journal of Arrhythmia
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Arrhythmia (2024)
Suggested Citation
Wattanachayakul P., Srikulmontri T., Prasitsumrit V., Suenghataiphorn T., Danpanichkul P., Polpichai N., Saowapa S., Idowu A., Amanullah A. Vitamin D as a predictor of clinical response among patients with cardiac resynchronization therapy (CRT). Journal of Arrhythmia (2024). doi:10.1002/joa3.13116 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/99771
Title
Vitamin D as a predictor of clinical response among patients with cardiac resynchronization therapy (CRT)
Corresponding Author(s)
Other Contributor(s)
Abstract
Introduction: Cardiovascular and noncardiovascular comorbidities have been recognized as predictors of clinical response in patients receiving cardiac resynchronization therapy (CRT). However, data on vitamin D as a predictor of CRT response are conflicting. Method: We identified studies from MEDLINE and Embase databases, searching from inception to May 2024, to investigate the association between 25-OH vitamin D levels before CRT implantation and outcomes. Studies had to report 25-OH vitamin D levels or the proportion of patients with vitamin D insufficiency and categorize outcomes as CRT responders or nonresponders. We extracted mean 25-OH vitamin D and standard deviations for both groups from each study and calculated the pooled mean difference (MD). We also retrieved risk ratios, and 95% confidence intervals (CIs) for the association between vitamin D insufficiency and lack of CRT response, combining them using the generic inverse variance method. Results: Our meta-analysis included four studies. CRT responders had higher levels of 25-OH vitamin D than nonresponders, with a pooled MD of 8.04 ng/mL (95% CI: 3.16–12.93; I2 = 48%, p <.001). Patients with vitamin D insufficiency before implantation had higher odds of lacking response to CRT, with a pooled RR of 3.28 (95% CI: 1.43–7.50; I2 = 0%, p =.005) compared to those with normal vitamin D. Conclusions: CRT responders had higher 25-OH vitamin D levels compared to nonresponders. Vitamin D insufficiency was associated with a higher risk of nonresponse to CRT. These findings highlight the importance of monitoring and managing vitamin D levels in these patients.