The impact of urinary calcium-binding and oxalate-binding proteins on modulation of calcium oxalate renal calculi
Issued Date
2026-02-01
Resource Type
ISSN
00039861
eISSN
10960384
Scopus ID
2-s2.0-105025717183
Pubmed ID
41443292
Journal Title
Archives of Biochemistry and Biophysics
Volume
776
Rights Holder(s)
SCOPUS
Bibliographic Citation
Archives of Biochemistry and Biophysics Vol.776 (2026)
Suggested Citation
Hadpech S., Peerapen P., Thongboonkerd V. The impact of urinary calcium-binding and oxalate-binding proteins on modulation of calcium oxalate renal calculi. Archives of Biochemistry and Biophysics Vol.776 (2026). doi:10.1016/j.abb.2025.110712 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/114857
Title
The impact of urinary calcium-binding and oxalate-binding proteins on modulation of calcium oxalate renal calculi
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Author's Affiliation
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Abstract
Cumulative data suggest that proteins with modulatory activities on calcium oxalate (CaOx) renal calculi commonly have calcium-binding and/or oxalate-binding domains/motifs. However, the information on calcium-binding proteins (CaBPs) and oxalate-binding proteins (OxBPs) in the urine of healthy individuals and stone formers was not available. Herein, we addressed the impact of urinary CaBPs and OxBPs on CaOx renal calculi. Large proteome datasets from recent/previous quantitative proteomics studies and all known CaOx stone modulatory proteins listed on the StoneMod ( www.stonemod.org ) database were retrieved and analyzed for calcium-binding and/or oxalate-binding domains/motifs. The data showed that %CaBPs decreased, whereas no. of oxalate-binding sites/protein increased in stone formers' urine. Among differentially excreted proteins, %CaBPs tended to reduce, whereas no. of oxalate-binding sites/protein tended to be greater in those with increased levels in stone formers’ urine. Interestingly, known CaOx stone inhibitory proteins tended to have greater %CaBPs and no. of calcium-binding sites/protein, whereas known CaOx promoters had no CaBPs and tended to have greater %OxBPs. Moreover, CaOx crystallization fold-change induced by the known modulators inversely correlated with no. of calcium-binding sites/protein. These data implicate the impact of CaBPs and OxBPs on CaOx renal calculi, i.e., CaBPs tend to inhibit, whereas OxBPs tend to promote CaOx calculi development.