Genomics of Plasmodium vivax in Colombia reveals evidence of local bottle-necking and inter-country connectivity in the Americas
Issued Date
2023-12-01
Resource Type
eISSN
20452322
Scopus ID
2-s2.0-85176434365
Journal Title
Scientific Reports
Volume
13
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Scientific Reports Vol.13 No.1 (2023)
Suggested Citation
Sutanto E., Pava Z., Echeverry D.F., Lopera-Mesa T.M., Montenegro L.M., Yasnot-Acosta M.F., Benavente E.D., Pearson R.D., Herrera S., Arévalo-Herrera M., Trimarsanto H., Rumaseb A., Noviyanti R., Kwiatkowski D.P., Price R.N., Auburn S. Genomics of Plasmodium vivax in Colombia reveals evidence of local bottle-necking and inter-country connectivity in the Americas. Scientific Reports Vol.13 No.1 (2023). doi:10.1038/s41598-023-46076-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/91118
Title
Genomics of Plasmodium vivax in Colombia reveals evidence of local bottle-necking and inter-country connectivity in the Americas
Author's Affiliation
Mahidol Oxford Tropical Medicine Research Unit
Universidad de Córdoba, Monteria
Eijkman Institute for Molecular Biology
Universidad del Valle, Cali
Universidad de Antioquia
Centro Internacional de Entrenamiento e Investigaciones Medicas
University Medical Center Utrecht
Menzies School of Health Research
Nuffield Department of Medicine
Wellcome Sanger Institute
Exeins Health Initiative
CAUCASECO SCIENTIFIC RESEARCH CENTER
Centro Internacional de Vacunas
Universidad de Córdoba, Monteria
Eijkman Institute for Molecular Biology
Universidad del Valle, Cali
Universidad de Antioquia
Centro Internacional de Entrenamiento e Investigaciones Medicas
University Medical Center Utrecht
Menzies School of Health Research
Nuffield Department of Medicine
Wellcome Sanger Institute
Exeins Health Initiative
CAUCASECO SCIENTIFIC RESEARCH CENTER
Centro Internacional de Vacunas
Other Contributor(s)
Abstract
Colombia aims to eliminate malaria by 2030 but remains one of the highest burden countries in the Americas. Plasmodium vivax contributes half of all malaria cases, with its control challenged by relapsing parasitaemia, drug resistance and cross-border spread. Using 64 Colombian P. vivax genomes collected between 2013 and 2017, we explored diversity and selection in two major foci of transmission: Chocó and Córdoba. Open-access data from other countries were used for comparative assessment of drug resistance candidates and to assess cross-border spread. Across Colombia, polyclonal infections were infrequent (12%), and infection connectivity was relatively high (median IBD = 5%), consistent with low endemicity. Chocó exhibited a higher frequency of polyclonal infections (23%) than Córdoba (7%), although the difference was not significant (P = 0.300). Most Colombian infections carried double pvdhfr (95%) and single pvdhps (71%) mutants, but other drug resistance mutations were less prevalent (< 10%). There was no evidence of selection at the pvaat1 gene, whose P. falciparum orthologue has recently been implicated in chloroquine resistance. Global population comparisons identified other putative adaptations. Within the Americas, low-level connectivity was observed between Colombia and Peru, highlighting potential for cross-border spread. Our findings demonstrate the potential of molecular data to inform on infection spread and adaptation.