Enhancing the Appropriate Use of Vancomycin in Pediatric Patients: The Impact of Drug Utilization Evaluation and Infectious Disease Consultation
Issued Date
2026-01-01
Resource Type
eISSN
30502225
Scopus ID
2-s2.0-105030083202
Journal Title
Sage Open Pediatrics
Volume
13
Rights Holder(s)
SCOPUS
Bibliographic Citation
Sage Open Pediatrics Vol.13 (2026)
Suggested Citation
Pongpatipat C., Boonsathorn S., Chaisavaneeyakorn S., Santanirand P., Techasaensiri C., Apiwattanakul N. Enhancing the Appropriate Use of Vancomycin in Pediatric Patients: The Impact of Drug Utilization Evaluation and Infectious Disease Consultation. Sage Open Pediatrics Vol.13 (2026). doi:10.1177/30502225261417259 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/115196
Title
Enhancing the Appropriate Use of Vancomycin in Pediatric Patients: The Impact of Drug Utilization Evaluation and Infectious Disease Consultation
Author's Affiliation
Corresponding Author(s)
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Abstract
Background: This study evaluated the impact of a drug utilization evaluation (DUE) program on vancomycin prescribing appropriateness and examined clinical factors, including infectious disease (ID) consultation, associated with appropriate use in a pediatric setting. Methods: A historical-control study was conducted among hospitalized children under 18 years who received intravenous vancomycin from January 2020 to January 2022. Prescriptions before DUE implementation were retrospectively reviewed (non-DUE group). From February 2021, a voluntary DUE program was introduced (DUE group). Demographic and clinical data were collected. Results: Among 423 prescriptions (232 non-DUE; 191 DUE), appropriateness was significantly higher in the DUE group (87.9% vs 72.0%; P < .001). DUE implementation (adjusted OR 2.96: 95% CI 1.44-6.10; P = .003) and ID consultation (adjusted OR 3.87: 95% CI 1.95-7.67; P < .001) were independently associated with appropriate vancomycin prescribing. Conclusion: Implementation of a DUE program improved vancomycin prescribing appropriateness, with ID consultation serving as an additional contributor to appropriate use.