Natural Bioactive Compounds Targeting Histone Deacetylases in Human Cancers: Recent Updates
Issued Date
2022-04-01
Resource Type
eISSN
14203049
Scopus ID
2-s2.0-85128802135
Pubmed ID
35458763
Journal Title
Molecules
Volume
27
Issue
8
Rights Holder(s)
SCOPUS
Bibliographic Citation
Molecules Vol.27 No.8 (2022)
Suggested Citation
Bouyahya A., El Hachlafi N., Aanniz T., Bourais I., Mechchate H., Benali T., Shariati M.A., Burkov P., Lorenzo J.M., Wilairatana P., Mubarak M.S., El Omari N. Natural Bioactive Compounds Targeting Histone Deacetylases in Human Cancers: Recent Updates. Molecules Vol.27 No.8 (2022). doi:10.3390/molecules27082568 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/84197
Title
Natural Bioactive Compounds Targeting Histone Deacetylases in Human Cancers: Recent Updates
Author's Affiliation
Faculty of Tropical Medicine, Mahidol University
Fundación Centro Tecnolóxico da Carne
South Ural State Agrarian University
Moscow State University of Technologies and Management
Faculté de Médecine et de Pharmacie de Rabat
The University of Jordan
Universidade de Vigo
Université Sidi Mohamed Ben Abdellah
Université Cadi Ayyad
Faculté des Sciences Rabat
Fundación Centro Tecnolóxico da Carne
South Ural State Agrarian University
Moscow State University of Technologies and Management
Faculté de Médecine et de Pharmacie de Rabat
The University of Jordan
Universidade de Vigo
Université Sidi Mohamed Ben Abdellah
Université Cadi Ayyad
Faculté des Sciences Rabat
Other Contributor(s)
Abstract
Cancer is a complex pathology that causes a large number of deaths worldwide. Several risk factors are involved in tumor transformation, including epigenetic factors. These factors are a set of changes that do not affect the DNA sequence, while modifying the gene’s expression. Histone modification is an essential mark in maintaining cellular memory and, therefore, loss of this mark can lead to tumor transformation. As these epigenetic changes are reversible, the use of molecules that can restore the functions of the enzymes responsible for the changes is therapeutically necessary. Natural molecules, mainly those isolated from medicinal plants, have demonstrated significant in-hibitory properties against enzymes related to histone modifications, particularly histone deacetylases (HDACs). Flavonoids, terpenoids, phenolic acids, and alkaloids exert significant inhibitory effects against HDAC and exhibit promising epi-drug properties. This suggests that epi-drugs against HDAC could prevent and treat various human cancers. Accordingly, the present study aimed to evaluate the pharmacodynamic action of different natural compounds extracted from medicinal plants against the enzymatic activity of HDAC.