Overdiagnosis of adrenal insufficiency in children with biliary atresia
Issued Date
2023-01-01
Resource Type
ISSN
09185739
eISSN
13477358
Scopus ID
2-s2.0-85163568853
Journal Title
Clinical Pediatric Endocrinology
Volume
32
Issue
3
Start Page
147
End Page
154
Rights Holder(s)
SCOPUS
Bibliographic Citation
Clinical Pediatric Endocrinology Vol.32 No.3 (2023) , 147-154
Suggested Citation
Ekawaravong S., Treepongkaruna S., Poomthavorn P., Pongratanakul S., Khlairit P., Chanprasertyothin S., Mahachoklertwattana P. Overdiagnosis of adrenal insufficiency in children with biliary atresia. Clinical Pediatric Endocrinology Vol.32 No.3 (2023) , 147-154. 154. doi:10.1297/cpe.2022-0083 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/87869
Title
Overdiagnosis of adrenal insufficiency in children with biliary atresia
Author's Affiliation
Other Contributor(s)
Abstract
Serum cortisol mainly binds to the cortisol-binding globulin (CBG). Children with biliary atresia (BA) may have low serum CBG levels; thus, low serum total cortisol (TC) levels and adrenal insufficiency (AI) may be overdiagnosed. This study aimed to assess adrenal function in children with BA. All the patients underwent adrenocorticotropic hormone (ACTH) stimulation tests. Plasma ACTH, serum TC, and CBG levels were measured at baseline, with additional TC measurements at 30 and 60 min during testing. Free cortisol (FC) index (FCI) and calculated FC (cFC) were also calculated. AI was defined as peak TC <500 nmol/L (<18 μg/dL), peak FCI <12 nmol/ mg, or peak cFC <33 nmol/L (<1.2 μg/dL). This study enrolled 71 children with BA. The Median (IQR) age of the patients was 5.5 (1.7–11.4) years. Twenty-five (35%) patients were diagnosed with AI based on the peak TC. In the AI group, the median serum CBG level was significantly lower than that in the non-AI group (481 vs. 533 nmol/L, p = 0.03). Only eight patients (11%) met all three AI criteria (six secondary AI and two primary AI). In conclusion, low serum CBG levels contribute to reduced peak TC and, consequently, overdiagnosing AI. Peak FCI and cFC could help reduce the overdiagnosis of AI.