Gold-Based Nanoparticles as an Additive for Combating Drug-Resistant Escherichia coli in Water-Based Paint
1
Issued Date
2025-11-25
Resource Type
eISSN
24701343
Scopus ID
2-s2.0-105022740638
Journal Title
ACS Omega
Volume
10
Issue
46
Start Page
55898
End Page
55908
Rights Holder(s)
SCOPUS
Bibliographic Citation
ACS Omega Vol.10 No.46 (2025) , 55898-55908
Suggested Citation
Poopakaphunpong R., Prakulpawong P., Pissuwan D. Gold-Based Nanoparticles as an Additive for Combating Drug-Resistant Escherichia coli in Water-Based Paint. ACS Omega Vol.10 No.46 (2025) , 55898-55908. 55908. doi:10.1021/acsomega.5c07469 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/113315
Title
Gold-Based Nanoparticles as an Additive for Combating Drug-Resistant Escherichia coli in Water-Based Paint
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Author's Affiliation
Corresponding Author(s)
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Abstract
The rise of drug-resistant Escherichia coli (E. coli) poses a major challenge in both healthcare and materials science, particularly with regard to surface hygiene. Wall surfaces, particularly those in high-contact areas, can act as breeding grounds for bacterial growth and serve as potential transmission points for harmful bacteria, including drug-resistant strains. Beyond health concerns, bacterial contamination can cause aesthetic damage through bacterial-induced discoloration, which is another significant problem. To address this issue, we proposed that incorporating gold-based nanoparticles (DP1-GNPs) as an antimicrobial additive in paints could enhance antibacterial properties, especially against drug-resistant bacterial strains. This study aimed to evaluate the antibacterial effectiveness of DP1-GNPs incorporated into paint against drug-resistant E. coli BAA-1161, which was used as a drug-resistant bacterial model strain. We systematically compared the bacterial viability on paint films with and without DP1-GNPs under nonscrubbed and scrubbed conditions. The results showed a reduction in bacterial viability upon immediate exposure on both scrubbed blank water-based paint without antimicrobial agents (BP) but containing DP1-GNPs (BP/DP1-GNPs; 69.55 ± 5.39% bacterial viability) and nonscrubbed BP/DP1-GNPs films (85.15 ± 4.11% bacterial viability). Notably, when the scrubbed BP/DP1-GNPs films were further treated with DP1-GNPs shield, the viability of E. coli BAA-1161 was reduced to 47.04 ± 2.41%, indicating the enhanced antibacterial performance of the shielded surface. Importantly, cytotoxicity tests indicate that lixiviated products of paint films containing DP1-GNPs were nontoxic to human skin fibroblasts, suggesting their safety on surfaces with frequent human contact. These findings highlight the potential of DP1-GNPs as antimicrobial additives in paint formulations, offering a promising strategy for combating drug-resistant bacterial contamination on painted surfaces.