Effect of Chinese celery on blood pressure in desoxycorticosterone acetate (DOCA) hypertensive dogs
1
Issued Date
2024
Copyright Date
1987
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
xiii, 93 leaves : ill.
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
Mahidol University
Bibliographic Citation
Thesis (M.Sc. (Physiology))--Mahidol University, 1987
Suggested Citation
Pornprapa Itsaramathangkurn Effect of Chinese celery on blood pressure in desoxycorticosterone acetate (DOCA) hypertensive dogs. Thesis (M.Sc. (Physiology))--Mahidol University, 1987. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/99330
Title
Effect of Chinese celery on blood pressure in desoxycorticosterone acetate (DOCA) hypertensive dogs
Alternative Title(s)
ผลของคื่นช่ายต่อความดันโลหิตในสุนัขที่ฉีดสารเดสออกซีคอร์ติโคสเตอโรนอะซิเตต
Author(s)
Advisor(s)
Abstract
This study was undertaken to investigate the antihypertensive and diuretic action of celery (Apium Graveolens Linn.) in DOCA-salt animal model. Celery is a green vegetable, about 1 foot high, used for several food preparation and it is also believed for quite a long time that celery can be used as a folk antihypertensive and diuretic agent. Several experiments showed that celery decoction could bring down the blood pressure of normotensive animals and possessed diuretic effect. The antihypertensive effect of celery in DOCA-salt animal model have never been reported yet. In this present study, hypertension in experimental dogs was induced by injecting desoxycorticosterone acetate 5 mg/kg body weight subcutaneously three times a week and giving 1% NaCl plus 0.25% KCl solution as their drinking water for at least two-three weeks before the operation. Blood samples for electrolyte assay were collected before and after one weed and two weeks of DOCA injection. All animals were weigned twice a week. After at least two weeks of DOCA injection, each dog was operated in order to record blood pressure and urine volume simultaneously and continuously, then given celery decoction or distilled water orally. Celery was capable of reducing both systolic and diastolic blood pressure immediately and significantly. It also caused slightly more diuresis than water feeding though statistically non-significant. The mild diuretic effect of celery occurs late after the decrease in blood pressure. These results suggest that, the hypotensive mecnanism of celery is, at least in part, due to lowering of the total peripheral resistance, but does not correlate mainly with the diuretic effect.
Description
Physiology (Mahidol University 1987)
Degree Name
Master of Science
Degree Level
Master's degree
Degree Department
Faculty of Science
Degree Discipline
Physiology
Degree Grantor(s)
Mahidol University