Functional genomics and systems biology of Cordyceps species for biotechnological applications
Issued Date
2023-06-01
Resource Type
ISSN
09581669
eISSN
18790429
Scopus ID
2-s2.0-85152475431
Pubmed ID
37075529
Journal Title
Current Opinion in Biotechnology
Volume
81
Rights Holder(s)
SCOPUS
Bibliographic Citation
Current Opinion in Biotechnology Vol.81 (2023)
Suggested Citation
Raethong N., Thananusak R., Cheawchanlertfa P., Prabhakaran P., Rattanaporn K., Laoteng K., Koffas M., Vongsangnak W. Functional genomics and systems biology of Cordyceps species for biotechnological applications. Current Opinion in Biotechnology Vol.81 (2023). doi:10.1016/j.copbio.2023.102939 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/81317
Title
Functional genomics and systems biology of Cordyceps species for biotechnological applications
Other Contributor(s)
Abstract
The use of Cordyceps species for the manufacture of natural products has been established; however, the tremendous advances observed in recent years in genetic engineering and molecular biology have revolutionized the optimization of Cordyceps as cell factories and drastically expanded the biotechnological potential of these fungi. Here, we present a review of systems and synthetic biology studies of Cordyceps and their implications for fungal biology and industrial applications. We summarize the current status of synthetic biology for enhancing targeted metabolites in Cordyceps species, such as cordycepin, adenosine, polysaccharide, and pentostatin. Progress in the systems and synthetic biology of Cordyceps provides a strategy for comprehensively comprehensive controlling efficient cell factories of natural bioproducts and novel synthetic biology toolbox for targeted engineering.