Right Ventricular Injury Definition and Management in Veno-Venous Extracorporeal Membrane Oxygenation
Issued Date
2025-01-01
Resource Type
ISSN
10582916
eISSN
1538943X
Scopus ID
2-s2.0-85215680876
Pubmed ID
39787611
Journal Title
ASAIO Journal
Rights Holder(s)
SCOPUS
Bibliographic Citation
ASAIO Journal (2025)
Suggested Citation
Dugar S.P., Sato R., Charlton M., Hasegawa D., Antonini M.V., Nasa P., Yusuff H., Schultz M.J., Harnegie M.P., Ramanathan K., Shekar K., Schmidt M., Zochios V., Duggal A. Right Ventricular Injury Definition and Management in Veno-Venous Extracorporeal Membrane Oxygenation. ASAIO Journal (2025). doi:10.1097/MAT.0000000000002369 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/103089
Title
Right Ventricular Injury Definition and Management in Veno-Venous Extracorporeal Membrane Oxygenation
Author's Affiliation
Mahidol Oxford Tropical Medicine Research Unit
College of Life Sciences
NMC Specialty Hospital
University of Leicester
National University Hospital
The University of Queensland
Beth Israel Medical Center
NUS Yong Loo Lin School of Medicine
Cleveland Clinic Foundation
Queen's Medical Center Hawaii
Ospedale M. Bufalini
Medizinische Universität Wien
Queensland University of Technology
Glenfield Hospital
Nuffield Department of Medicine
Università degli Studi di Modena e Reggio Emilia
The Prince Charles Hospital
Sorbonne Université
Amsterdam UMC - University of Amsterdam
Case Western Reserve University
College of Medicine and Health Sciences
College of Life Sciences
NMC Specialty Hospital
University of Leicester
National University Hospital
The University of Queensland
Beth Israel Medical Center
NUS Yong Loo Lin School of Medicine
Cleveland Clinic Foundation
Queen's Medical Center Hawaii
Ospedale M. Bufalini
Medizinische Universität Wien
Queensland University of Technology
Glenfield Hospital
Nuffield Department of Medicine
Università degli Studi di Modena e Reggio Emilia
The Prince Charles Hospital
Sorbonne Université
Amsterdam UMC - University of Amsterdam
Case Western Reserve University
College of Medicine and Health Sciences
Corresponding Author(s)
Other Contributor(s)
Abstract
Right ventricular injury (RVI) in respiratory failure receiving veno-venous extracorporeal membrane oxygenation (VV ECMO) is associated with significant mortality. A scoping review is necessary to map the current literature and guide future research regarding the definition and management of RVI in patients receiving VV ECMO. We searched for relevant publications on RVI in patients receiving VV ECMO in Medline, EMBASE, and Web of Science. Of 1,868 citations screened, 30 studies reported on RVI (inclusive of right ventricular dilation, right ventricular dysfunction, and right ventricular failure) during VV ECMO. Twenty-three studies reported on the definition of RVI including echocardiographic indices of RV function and dimensions, whereas 13 studies reported on the management of RVI, including veno-pulmonary (VP) ECMO, veno-arterial (VA) ECMO, positive inotropic agents, pulmonary vasodilators, ultra-lung-protective ventilation (Ultra-LPV), and optimization of positive end-expiratory pressure (PEEP). The definitions of RVI in patients receiving VV ECMO used in the literature are heterogeneous. Despite the high incidence of RVI during VV ECMO support and its strong association with mortality, studies investigating therapeutic strategies for RVI are also lacking. To fill the existing knowledge gaps, a consensus on the definition of RVI and research investigating RV-targeted therapies during VV ECMO is urgently warranted.