Genetic surveillance of Plasmodium falciparum populations following treatment policy revisions in the Greater Mekong Subregion

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dc.contributor.authorWasakul V.
dc.contributor.authorVerschuuren T.D.
dc.contributor.authorThuy-Nhien N.
dc.contributor.authorBooth E.
dc.contributor.authorQuang H.H.
dc.contributor.authorThang N.D.
dc.contributor.authorChindavongsa K.
dc.contributor.authorSovannaroth S.
dc.contributor.authorBanouvong V.
dc.contributor.authorSengsavath V.
dc.contributor.authorMayxay M.
dc.contributor.authorTuyen N.T.K.
dc.contributor.authorPhuong V.N.L.
dc.contributor.authorDuc Trung P.
dc.contributor.authorGonçalves S.
dc.contributor.authorChen S.
dc.contributor.authorPhalivong S.
dc.contributor.authorXayvanghang S.
dc.contributor.authorMahaphontrakoon S.
dc.contributor.authorPearson R.D.
dc.contributor.authorNewton P.N.
dc.contributor.authorMaude R.J.
dc.contributor.authorAshley E.A.
dc.contributor.authorAriani C.V.
dc.contributor.authorSimpson V.J.
dc.contributor.authorDay N.P.
dc.contributor.authorDondorp A.M.
dc.contributor.authorMiotto O.
dc.contributor.correspondenceWasakul V.
dc.contributor.otherMahidol University
dc.date.accessioned2025-05-26T18:08:04Z
dc.date.available2025-05-26T18:08:04Z
dc.date.issued2025-12-01
dc.description.abstractGenetic surveillance of Plasmodium falciparum (Pf) can track antimalarial-resistant strains, to inform decision-making by National Malaria Control Programmes (NMCPs). The GenRe-Mekong project prospectively collected 5982 samples in the Greater Mekong Subregion (GMS) between 2017 and 2022, genotyping drug resistance markers, and barcodes that recapitulate genetic variation. Genotypes were analyzed with the grcMalaria R package, first described in this paper, to translate genetic epidemiology data into actionable visual information. Since 2020, Pf incidences decreased rapidly, accompanied by a decline of dihydroartemisinin-piperaquine (DHA-PPQ) resistant lineages, previously dominant in the eastern GMS. The frequency of plasmepsin2/3 amplifications, conferring piperaquine resistance, dropped from 62% in 2017-2019 to 2% in 2022, coinciding with a switch in frontline therapy in Cambodia, Thailand, and Vietnam. While regional artemisinin resistance levels remained high, no evidence of emerging mefloquine resistance was found. Routine genetic surveillance proved valuable in monitoring rapid parasite population changes in response to public health interventions, providing actionable information for NMCPs.
dc.identifier.citationNature Communications Vol.16 No.1 (2025)
dc.identifier.doi10.1038/s41467-025-59946-1
dc.identifier.eissn20411723
dc.identifier.scopus2-s2.0-105005555841
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/110357
dc.rights.holderSCOPUS
dc.subjectChemistry
dc.subjectBiochemistry, Genetics and Molecular Biology
dc.subjectPhysics and Astronomy
dc.titleGenetic surveillance of Plasmodium falciparum populations following treatment policy revisions in the Greater Mekong Subregion
dc.typeArticle
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=105005555841&origin=inward
oaire.citation.issue1
oaire.citation.titleNature Communications
oaire.citation.volume16
oairecerif.author.affiliationMahidol Oxford Tropical Medicine Research Unit
oairecerif.author.affiliationOxford University Clinical Research Unit
oairecerif.author.affiliationMinistry of Health Laos
oairecerif.author.affiliationNational Institute of Malariology, Parasitology and Entomology Hanoi
oairecerif.author.affiliationNational University of Singapore
oairecerif.author.affiliationMahosot Hospital, Lao
oairecerif.author.affiliationThe Open University
oairecerif.author.affiliationNuffield Department of Medicine
oairecerif.author.affiliationWellcome Sanger Institute
oairecerif.author.affiliationInstitute of Malariology
oairecerif.author.affiliationNational Center for Parasitology
oairecerif.author.affiliationCentre of Malariology

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