Determination of volume-specific correction factors and geometry effects of<sup>90</sup>Y activity measurement in dose calibrators
Issued Date
2023-01-01
Resource Type
eISSN
25396056
Scopus ID
2-s2.0-85145303323
Journal Title
Journal of Associated Medical Sciences
Volume
56
Issue
1
Start Page
182
End Page
186
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Associated Medical Sciences Vol.56 No.1 (2023) , 182-186
Suggested Citation
Phomtum D. Determination of volume-specific correction factors and geometry effects of<sup>90</sup>Y activity measurement in dose calibrators. Journal of Associated Medical Sciences Vol.56 No.1 (2023) , 182-186. 186. doi:10.12982/JAMS.2023.022 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/81909
Title
Determination of volume-specific correction factors and geometry effects of<sup>90</sup>Y activity measurement in dose calibrators
Author(s)
Other Contributor(s)
Abstract
Background: Yttrium-90 (90Y) is widely used in nuclear medicine for therapeutic purposes. The radiation dose of radiopharmaceuticals relates to the activity of the radionuclide which is measured in the dose calibrator during radiopharmaceutical preparations. Objectives: The objectives of this study were to determine volume-specific correction factors and investigate the geometry effects of90Y activity measurement in dose calibrators. Materials and methods: Four dose calibrators from two institutes were independently measured. The 3-mL plastic syringe and the 10-mL glass vial were used to investigate the geometry effects using the initial calibration factors for each dose calibrator. The comparison between actual activity and measured activity was expressed as the percentage errors. For volume-specific correction factor, the value for each volume was calculated based on the actual and measured activity at 0.5, 1.0, 1.5, 2.0 and 2.5 mL. Results: Percentage error showed that90Y activity measured in the 3-mL plastic syringe and the 10-mL glass vial were inaccurate. The activity measurements in the 3-mL plastic syringe were more accurate than in the 10-mL glass vial at all volumes for both containers in all dose calibrators. Our findings showed that increasing the volume of90Y could result in underestimate of the measured activity. The maximum volume dependence in the 10-mL glass vial was about 20%. Hence, the volume-specific correction factors were determined for the 3-mL plastic syringe and the 10-mL glass vial for all dose calibrators. Conclusion: The geometry effect could impact the90Y activity measurement on the dose calibrators. Using the volume-specific correction factor for each geometry of 90 Y to compensate for the geometry effect could improve the accuracy of90Yactivity measurement. However, the volume-specific correction factors are depended on the dose calibrators. Therefore, the institutes need to establish their own volume-specific correction factors for90Y activity measurement.