Rates, types, and associated factors of acute adverse effects after the first dose of ChAdOx1 nCoV-19 vaccine administration in Thailand
Issued Date
2022-03-01
Resource Type
eISSN
27727076
Scopus ID
2-s2.0-85137739770
Journal Title
IJID Regions
Volume
2
Start Page
35
End Page
39
Rights Holder(s)
SCOPUS
Bibliographic Citation
IJID Regions Vol.2 (2022) , 35-39
Suggested Citation
Watcharananan S.A. Rates, types, and associated factors of acute adverse effects after the first dose of ChAdOx1 nCoV-19 vaccine administration in Thailand. IJID Regions Vol.2 (2022) , 35-39. 39. doi:10.1016/j.ijregi.2021.11.008 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/87351
Title
Rates, types, and associated factors of acute adverse effects after the first dose of ChAdOx1 nCoV-19 vaccine administration in Thailand
Author(s)
Other Contributor(s)
Abstract
Objectives: Effective vaccines are prioritized to curtail the transmission and burden of coronavirus disease 2019. Nevertheless, monitoring the safety of vaccines is crucial. As Thailand began the ChAdOx1 nCoV-19 vaccination, our study examined the acute adverse effects and associated factors after the first dose of vaccination. Methods: A mobile self-report questionnaire was employed to assess the rates and types of different side-effects within 3 days of the first dose of ChAdOx1 nCoV-19 vaccine administration. The risk factors associated with these side-effects were analyzed. Results: In total, 774 participants were included in the survey, with a mean (± standard deviation) age of 49.5 (± 17.2) years. The majority (57.8%) were females, and 59.1% were anxious before the vaccination. Side-effects after the vaccination were a common occurrence (65.2%), but most (42.6%) were mild. Side-effects were significantly associated (odds ratio [95% confidence interval]) with younger age (4.32 [2.26–8.23]; p < 0.001; age < 30 years vs ≥ 60 years), female sex (1.66 [1.19–2.30], p = 0.003), anxiousness (2.10 [1.06–4.13]; p = 0.033; moderate–severe anxiousness vs none), and allergic disease (2.60 [1.07–6.31]; p = 0.035). Conclusions: After the ChAdOx1 nCoV-19 vaccination, most acute adverse effects were mild and often noted among participants with younger age, female sex, anxiousness, and allergic disease.