Pharmacoepidemiology and Clinical Correlates of Lithium Treatment for Bipolar Disorder in Asia
4
Issued Date
2024-03-01
Resource Type
eISSN
1533712X
Scopus ID
2-s2.0-85186751437
Pubmed ID
38230861
Journal Title
Journal of clinical psychopharmacology
Volume
44
Issue
2
Start Page
117
End Page
123
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of clinical psychopharmacology Vol.44 No.2 (2024) , 117-123
Suggested Citation
Shuy Y.K., Santharan S., Chew Q.H., Lin S.K., Ouyang W.C., Chen C.K., Park S.C., Jang O.J., Park J.H., Chee K.Y., Ding K.S., Chong J., Zhang L., Li K., Zhu X., Jatchavala C., Pariwatcharakul P., Kallivayalil R.A., Grover S., Avasthi A., Ansari M., Maramis M.M., Aung P.P., Tan C.H., Xiang Y.T., Chong M.Y., Park Y.C., Kato T.A., Shinfuku N., Baldessarini R.J., Sim K. Pharmacoepidemiology and Clinical Correlates of Lithium Treatment for Bipolar Disorder in Asia. Journal of clinical psychopharmacology Vol.44 No.2 (2024) , 117-123. 123. doi:10.1097/JCP.0000000000001813 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/97616
Title
Pharmacoepidemiology and Clinical Correlates of Lithium Treatment for Bipolar Disorder in Asia
Author(s)
Shuy Y.K.
Santharan S.
Chew Q.H.
Lin S.K.
Ouyang W.C.
Chen C.K.
Park S.C.
Jang O.J.
Park J.H.
Chee K.Y.
Ding K.S.
Chong J.
Zhang L.
Li K.
Zhu X.
Jatchavala C.
Pariwatcharakul P.
Kallivayalil R.A.
Grover S.
Avasthi A.
Ansari M.
Maramis M.M.
Aung P.P.
Tan C.H.
Xiang Y.T.
Chong M.Y.
Park Y.C.
Kato T.A.
Shinfuku N.
Baldessarini R.J.
Sim K.
Santharan S.
Chew Q.H.
Lin S.K.
Ouyang W.C.
Chen C.K.
Park S.C.
Jang O.J.
Park J.H.
Chee K.Y.
Ding K.S.
Chong J.
Zhang L.
Li K.
Zhu X.
Jatchavala C.
Pariwatcharakul P.
Kallivayalil R.A.
Grover S.
Avasthi A.
Ansari M.
Maramis M.M.
Aung P.P.
Tan C.H.
Xiang Y.T.
Chong M.Y.
Park Y.C.
Kato T.A.
Shinfuku N.
Baldessarini R.J.
Sim K.
Author's Affiliation
Chang Gung University School of Medicine
Siriraj Hospital
Graduate School of Medical Sciences
The Affiliated Guangji Hospital of Soochow University
Lee Kong Chian School of Medicine
Jeju National University Hospital
Beijing Anding Hospital, Capital Medical University
Hanyang University Guri Hospital
University of Yangon
Universitas Airlangga
Liaquat University of Medical and Health Sciences
Chang Gung Memorial Hospital
Kuala Lumpur Hospital
Faculty of Medicine, Prince of Songkla University
Seinan Gakuin University
National University of Singapore
Kementerian Kesihatan Malaysia
Singapore Institute of Mental Health
Postgraduate Institute of Medical Education & Research, Chandigarh
Hospital Bahagia Ulu Kinta
Pushpagiri Institute of Medical Sciences
Bugok National Hospital
Institute of Mental Health
Hebei Provincial Mental Health Center
Siriraj Hospital
Graduate School of Medical Sciences
The Affiliated Guangji Hospital of Soochow University
Lee Kong Chian School of Medicine
Jeju National University Hospital
Beijing Anding Hospital, Capital Medical University
Hanyang University Guri Hospital
University of Yangon
Universitas Airlangga
Liaquat University of Medical and Health Sciences
Chang Gung Memorial Hospital
Kuala Lumpur Hospital
Faculty of Medicine, Prince of Songkla University
Seinan Gakuin University
National University of Singapore
Kementerian Kesihatan Malaysia
Singapore Institute of Mental Health
Postgraduate Institute of Medical Education & Research, Chandigarh
Hospital Bahagia Ulu Kinta
Pushpagiri Institute of Medical Sciences
Bugok National Hospital
Institute of Mental Health
Hebei Provincial Mental Health Center
Corresponding Author(s)
Other Contributor(s)
Abstract
BACKGROUND: As clinical practices with lithium salts for patients diagnosed with bipolar disorder (BD) are poorly documented in Asia, we studied the prevalence and clinical correlates of lithium use there to support international comparisons. METHODS: We conducted a cross-sectional study of use and dosing of lithium salts for BD patients across 13 Asian sites and evaluated bivariate relationships of lithium treatment with clinical correlates followed by multivariate logistic regression modeling. RESULTS: In a total of 2139 BD participants (52.3% women) of mean age 42.4 years, lithium salts were prescribed in 27.3% of cases overall, varying among regions from 3.20% to 59.5%. Associated with lithium treatment were male sex, presence of euthymia or mild depression, and a history of seasonal mood change. Other mood stabilizers usually were given with lithium, often at relatively high doses. Lithium use was associated with newly emerging and dose-dependent risk of tremors as well as risk of hypothyroidism. We found no significant differences in rates of clinical remission or of suicidal behavior if treatment included lithium or not. CONCLUSIONS: Study findings clarify current prevalence, dosing, and clinical correlates of lithium treatment for BD in Asia. This information should support clinical decision-making regarding treatment of BD patients and international comparisons of therapeutic practices.