Midterm cardiovascular outcomes in children with MIS-C compared to Kawasaki disease: a multicenter prospective cohort study
Issued Date
2026-12-01
Resource Type
eISSN
20452322
Scopus ID
2-s2.0-105026947776
Pubmed ID
41318810
Journal Title
Scientific Reports
Volume
16
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Scientific Reports Vol.16 No.1 (2026)
Suggested Citation
Khrongsrattha S., Vijarnsorn C., Santimahakullert K., Hongkan W., Petarwut N., Srivichean A., Thammasate P., Pacharapakornpong T., Kanjanauthai S., Chungsomprasong P., Chanthong P., Durongpisitkul K., Soongswang J. Midterm cardiovascular outcomes in children with MIS-C compared to Kawasaki disease: a multicenter prospective cohort study. Scientific Reports Vol.16 No.1 (2026). doi:10.1038/s41598-025-30867-9 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/114485
Title
Midterm cardiovascular outcomes in children with MIS-C compared to Kawasaki disease: a multicenter prospective cohort study
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Corresponding Author(s)
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Abstract
The overlapping features of multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease (KD) raise concerns regarding midterm cardiovascular sequelae. We conducted a multicenter prospective cohort study to compare midterm outcomes in MIS-C and KD survivors. A total of 122 children (MIS-C, n = 66; KD, n = 56) underwent echocardiographic follow-up 1–3 years post-diagnosis. Outcomes included left ventricular ejection fraction (LVEF), coronary abnormalities, and left ventricular global longitudinal strain (LVGLS). Notably, the median age at diagnosis was higher in MIS-C (5.7 years, IQR 3.0–9.4) than in KD (1.5 years, IQR 1.1–2.8) (P < 0.01). Initial left ventricular dysfunction occurred more frequently in MIS-C (25.8%) than KD (0%) (P < 0.01). By the median follow-up of 1.5 years (IQR 1.1–1.9), all patients who had previously been diagnosed with left ventricular dysfunction had recovered to normal LVEF in both groups. However, one MIS-C patient had persistently abnormal LVGLS, suggesting subclinical impairment. Coronary abnormalities in MIS-C decreased from 30% at baseline to 1.5% at follow-up. In contrast, persistent coronary abnormalities remained in KD, despite preserved cardiac function and LVGLS. At follow-up, coronary abnormalities including coronary ectasia and aneurysm were significantly higher in KD (14.2%) compared with MIS-C (1.5%) (P < 0.01). In conclusion, MIS-C was associated with transient ventricular dysfunction but rare persistent coronary involvement, whereas KD carried a higher burden of midterm coronary abnormalities. Clinical trial registration: TCTR20230414003.