Neonatal mortality risk of vulnerable newborns: A descriptive analysis of subnational, population-based birth cohorts for 238 143 live births in low- and middle-income settings from 2000 to 2017
Issued Date
2023-01-01
Resource Type
ISSN
14700328
eISSN
14710528
Scopus ID
2-s2.0-85158148856
Journal Title
BJOG: An International Journal of Obstetrics and Gynaecology
Rights Holder(s)
SCOPUS
Bibliographic Citation
BJOG: An International Journal of Obstetrics and Gynaecology (2023)
Suggested Citation
Hazel E.A., Erchick D.J., Katz J., Lee A.C.C., Diaz M., Wu L.S.F., West K.P., Shamim A.A., Christian P., Ali H., Baqui A.H., Saha S.K., Ahmed S., Roy A.D., Silveira M.F., Buffarini R., Shapiro R., Zash R., Kolsteren P., Lachat C., Huybregts L., Roberfroid D., Zhu Z., Zeng L., Gebreyesus S.H., Tesfamariam K., Adu-Afarwuah S., Dewey K.G., Gyaase S., Poku-Asante K., Boamah Kaali E., Jack D., Ravilla T., Tielsch J., Taneja S., Chowdhury R., Ashorn P., Maleta K., Ashorn U., Mangani C., Mullany L.C., Khatry S.K., Ramokolo V., Zembe-Mkabile W., Fawzi W.W., Wang D., Schmiegelow C., Minja D., Msemo O.A., Lusingu J.P.A., Smith E.R., Masanja H., Mongkolchati A., Keentupthai P., Kakuru A., Kajubi R., Semrau K., Hamer D.H., Manasyan A., Pry J.M., Chasekwa B., Humphrey J., Black R.E., Klemm R.D.W., Massie A.B., Mitra M., Mehra S., Schulze K.J., Sommer A., Ullah M.B., Labrique A.B., Rashid M., Shaikh S., Begum N., Chowdhury N.H., Islam M.S., Khanam R., Mitra D.K., Quaiyum A., Diseko M., Makhema J., Cheng Y., Roro M., Endris B.S., Arnold C.D., Bahl R., Bhandari N., Martines J., Mazumder S., Hallamaa L., Pyykkö J., Urassa W., Deloron P., Bygbjerg I.C., Moeller S.L., Theander T.G., Muhihi A., Noor R.A., Kamya M.R., Nakalembe M. Neonatal mortality risk of vulnerable newborns: A descriptive analysis of subnational, population-based birth cohorts for 238 143 live births in low- and middle-income settings from 2000 to 2017. BJOG: An International Journal of Obstetrics and Gynaecology (2023). doi:10.1111/1471-0528.17518 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82473
Title
Neonatal mortality risk of vulnerable newborns: A descriptive analysis of subnational, population-based birth cohorts for 238 143 live births in low- and middle-income settings from 2000 to 2017
Author(s)
Hazel E.A.
Erchick D.J.
Katz J.
Lee A.C.C.
Diaz M.
Wu L.S.F.
West K.P.
Shamim A.A.
Christian P.
Ali H.
Baqui A.H.
Saha S.K.
Ahmed S.
Roy A.D.
Silveira M.F.
Buffarini R.
Shapiro R.
Zash R.
Kolsteren P.
Lachat C.
Huybregts L.
Roberfroid D.
Zhu Z.
Zeng L.
Gebreyesus S.H.
Tesfamariam K.
Adu-Afarwuah S.
Dewey K.G.
Gyaase S.
Poku-Asante K.
Boamah Kaali E.
Jack D.
Ravilla T.
Tielsch J.
Taneja S.
Chowdhury R.
Ashorn P.
Maleta K.
Ashorn U.
Mangani C.
Mullany L.C.
Khatry S.K.
Ramokolo V.
Zembe-Mkabile W.
Fawzi W.W.
Wang D.
Schmiegelow C.
Minja D.
Msemo O.A.
Lusingu J.P.A.
Smith E.R.
Masanja H.
Mongkolchati A.
Keentupthai P.
Kakuru A.
Kajubi R.
Semrau K.
Hamer D.H.
Manasyan A.
Pry J.M.
Chasekwa B.
Humphrey J.
Black R.E.
Klemm R.D.W.
Massie A.B.
Mitra M.
Mehra S.
Schulze K.J.
Sommer A.
Ullah M.B.
Labrique A.B.
Rashid M.
Shaikh S.
Begum N.
Chowdhury N.H.
Islam M.S.
Khanam R.
Mitra D.K.
Quaiyum A.
Diseko M.
Makhema J.
Cheng Y.
Roro M.
Endris B.S.
Arnold C.D.
Bahl R.
Bhandari N.
Martines J.
Mazumder S.
Hallamaa L.
Pyykkö J.
Urassa W.
Deloron P.
Bygbjerg I.C.
Moeller S.L.
Theander T.G.
Muhihi A.
Noor R.A.
Kamya M.R.
Nakalembe M.
Erchick D.J.
Katz J.
Lee A.C.C.
Diaz M.
Wu L.S.F.
West K.P.
Shamim A.A.
Christian P.
Ali H.
Baqui A.H.
Saha S.K.
Ahmed S.
Roy A.D.
Silveira M.F.
Buffarini R.
Shapiro R.
Zash R.
Kolsteren P.
Lachat C.
Huybregts L.
Roberfroid D.
Zhu Z.
Zeng L.
Gebreyesus S.H.
Tesfamariam K.
Adu-Afarwuah S.
Dewey K.G.
Gyaase S.
Poku-Asante K.
Boamah Kaali E.
Jack D.
Ravilla T.
Tielsch J.
Taneja S.
Chowdhury R.
Ashorn P.
Maleta K.
Ashorn U.
Mangani C.
Mullany L.C.
Khatry S.K.
Ramokolo V.
Zembe-Mkabile W.
Fawzi W.W.
Wang D.
Schmiegelow C.
Minja D.
Msemo O.A.
Lusingu J.P.A.
Smith E.R.
Masanja H.
Mongkolchati A.
Keentupthai P.
Kakuru A.
Kajubi R.
Semrau K.
Hamer D.H.
Manasyan A.
Pry J.M.
Chasekwa B.
Humphrey J.
Black R.E.
Klemm R.D.W.
Massie A.B.
Mitra M.
Mehra S.
Schulze K.J.
Sommer A.
Ullah M.B.
Labrique A.B.
Rashid M.
Shaikh S.
Begum N.
Chowdhury N.H.
Islam M.S.
Khanam R.
Mitra D.K.
Quaiyum A.
Diseko M.
Makhema J.
Cheng Y.
Roro M.
Endris B.S.
Arnold C.D.
Bahl R.
Bhandari N.
Martines J.
Mazumder S.
Hallamaa L.
Pyykkö J.
Urassa W.
Deloron P.
Bygbjerg I.C.
Moeller S.L.
Theander T.G.
Muhihi A.
Noor R.A.
Kamya M.R.
Nakalembe M.
Author's Affiliation
Kamuzu University of Health Sciences
Ariadne Labs
Infectious Diseases Research Collaboration
Belgian Health Care Knowledge Centre
Nepal Nutrition Intervention Project-Sarlahi
Centre for Infectious Disease Research in Zambia
Kintampo Health Research Centre
Ghana Health Service
Ifakara Health Institute
Addis Ababa University
National Institute For Medical Research Tanzania
Society for Applied Studies Kolkata
Universiteit Gent
Harvard T.H. Chan School of Public Health
Milken Institute School of Public Health
Ubon Ratchathani University
Beth Israel Deaconess Medical Center
School of Basic Medical Sciences
South African Medical Research Council
The University of Alabama at Birmingham
Boston University
School of Public Health
George Mason University
University of Ghana
Brigham and Women's Hospital
Copenhagen University Hospital
Universidade Federal de Pelotas
University of California, Davis
Gertrude H. Sergievsky Center
Mailman School of Public Health
Mahidol University
Tampere University
BRAC University
University Hospital of Tampere
Aravind Eye Hospital
University of Namur
Johns Hopkins Bloomberg School of Public Health
Harvard Medical School
University of South Africa
International Food Policy Research Institute
JiVitA Maternal and Child Health & Nutrition Research Project
Projahnmo Research Foundation
Zvitambo Institute for Maternal and Child Health Research
Child Health Research Foundation
Ariadne Labs
Infectious Diseases Research Collaboration
Belgian Health Care Knowledge Centre
Nepal Nutrition Intervention Project-Sarlahi
Centre for Infectious Disease Research in Zambia
Kintampo Health Research Centre
Ghana Health Service
Ifakara Health Institute
Addis Ababa University
National Institute For Medical Research Tanzania
Society for Applied Studies Kolkata
Universiteit Gent
Harvard T.H. Chan School of Public Health
Milken Institute School of Public Health
Ubon Ratchathani University
Beth Israel Deaconess Medical Center
School of Basic Medical Sciences
South African Medical Research Council
The University of Alabama at Birmingham
Boston University
School of Public Health
George Mason University
University of Ghana
Brigham and Women's Hospital
Copenhagen University Hospital
Universidade Federal de Pelotas
University of California, Davis
Gertrude H. Sergievsky Center
Mailman School of Public Health
Mahidol University
Tampere University
BRAC University
University Hospital of Tampere
Aravind Eye Hospital
University of Namur
Johns Hopkins Bloomberg School of Public Health
Harvard Medical School
University of South Africa
International Food Policy Research Institute
JiVitA Maternal and Child Health & Nutrition Research Project
Projahnmo Research Foundation
Zvitambo Institute for Maternal and Child Health Research
Child Health Research Foundation
Other Contributor(s)
Abstract
Objective: We aimed to understand the mortality risks of vulnerable newborns (defined as preterm and/or born weighing smaller or larger compared to a standard population), in low- and middle-income countries (LMICs). Design: Descriptive multi-country, secondary analysis of individual-level study data of babies born since 2000. Setting: Sixteen subnational, population-based studies from nine LMICs in sub-Saharan Africa, Southern and Eastern Asia, and Latin America. Population: Live birth neonates. Methods: We categorically defined five vulnerable newborn types based on size (large- or appropriate- or small-for-gestational age [LGA, AGA, SGA]), and term (T) and preterm (PT): T + LGA, T + SGA, PT + LGA, PT + AGA, and PT + SGA, with T + AGA (reference). A 10-type definition included low birthweight (LBW) and non-LBW, and a four-type definition collapsed AGA/LGA into one category. We performed imputation for missing birthweights in 13 of the studies. Main Outcome Measures: Median and interquartile ranges by study for the prevalence, mortality rates and relative mortality risks for the four, six and ten type classification. Results: There were 238 143 live births with known neonatal status. Four of the six types had higher mortality risk: T + SGA (median relative risk [RR] 2.8, interquartile range [IQR] 2.0–3.2), PT + LGA (median RR 7.3, IQR 2.3–10.4), PT + AGA (median RR 6.0, IQR 4.4–13.2) and PT + SGA (median RR 10.4, IQR 8.6–13.9). T + SGA, PT + LGA and PT + AGA babies who were LBW, had higher risk compared with non-LBW babies. Conclusions: Small and/or preterm babies in LIMCs have a considerably increased mortality risk compared with babies born at term and larger. This classification system may advance the understanding of the social determinants and biomedical risk factors along with improved treatment that is critical for newborn health.