Comparison of sinus distribution between nasal irrigation and nasal spray using fluorescein-labelled in patients with chronic rhinosinusitis: A randomised clinical trial
Issued Date
2023-03-01
Resource Type
ISSN
17494478
eISSN
17494486
Scopus ID
2-s2.0-85131539121
Pubmed ID
35638864
Journal Title
Clinical Otolaryngology
Volume
48
Issue
2
Start Page
286
End Page
293
Rights Holder(s)
SCOPUS
Bibliographic Citation
Clinical Otolaryngology Vol.48 No.2 (2023) , 286-293
Suggested Citation
Muenkaew Y., Tangbumrungtham N., Roongpuvapaht B., Tanjararak K. Comparison of sinus distribution between nasal irrigation and nasal spray using fluorescein-labelled in patients with chronic rhinosinusitis: A randomised clinical trial. Clinical Otolaryngology Vol.48 No.2 (2023) , 286-293. 293. doi:10.1111/coa.13951 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85129
Title
Comparison of sinus distribution between nasal irrigation and nasal spray using fluorescein-labelled in patients with chronic rhinosinusitis: A randomised clinical trial
Author's Affiliation
Other Contributor(s)
Abstract
Objective: This study aims to compare the potential sinus distribution between high-volume nasal irrigation and nasal spray in chronic rhinosinusitis (CRS) patients who have not undergone sinus surgery. Design and Setting: A randomised clinical study was conducted at the Otolaryngology-Head & Neck Surgery Department, Ramathibodi Hospital, Faculty of Medicine, Mahidol University. Participants: Forty patients undergoing endoscopic sinus surgery (ESS) for CRS. Thirty-eight patients met the inclusion criteria and were randomly assigned to receive nasal irrigation or nasal spray mixed with fluorescein sodium preoperatively. Main Outcome Measures: The primary outcome was the mean difference in the staining score of fluorescein in all sinuses between the two groups. Results: The total fluorescein staining score for all sinuses in the nasal irrigation group was significantly higher than the score from the nasal spray group, with a mean difference score of 2.90, 95% confidence interval: 1.22–4.58, p =.001. The most significantly affected sinuses were the maxillary and the anterior ethmoid sinuses, while the frontal and sphenoid sinuses had only minimal staining from both techniques. Conclusion: Nasal irrigation is a potential route to deliver drugs into the sinus in unoperated CRS patients. However, it is not considered a superior method to nasal spray in the most challenging anatomical areas, that is, the frontal and sphenoid sinuses.