Effects of prenatal and adult capsaicin treatment on nociceptive thresholds and neurogenic plasma extravasation
3
Issued Date
1987
Copyright Date
1987
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
ix, 107 p. : ill.
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
Mahidol University
Bibliographic Citation
Thesis (M.Sc. (Physiology))--Mahidol University, 1987
Suggested Citation
Viroj Vithayaveroj Effects of prenatal and adult capsaicin treatment on nociceptive thresholds and neurogenic plasma extravasation. Thesis (M.Sc. (Physiology))--Mahidol University, 1987. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/103361
Title
Effects of prenatal and adult capsaicin treatment on nociceptive thresholds and neurogenic plasma extravasation
Alternative Title(s)
ผลของสารเผ็ดแคปไซซินที่ฉีดผ่านแม่หนูที่ตั้งท้องต่อระดับความเจ็บปวดและการรั้วของน้ำเลือด (พลาสมา) ในลูกหนู
Author(s)
Abstract
Capsaicin (8-methyl-N-vanillyl-6-nonenamide), a pungent substance of chilli pepper, Capsicum minimum, was administered subcutaneously to the pregnant rats of Wistar strain, on day 5 or day 15 of gestations, with a single dose of 10, 20 or 50 mg/kg or multiple doses of 10 mg/kg for 5 consecutive days. Three weanling pups of both sexes (21 days of age) from each litters were randomly selected, and subjected to determination of thermal pain thresholds, tested by the hot plate (55 degree C) and tail immersion (50 degree C), and the mechanical pain thresholds. In prenatally capsaicin treated rats both thermal and mechanical pain thresholds were not significantly different from those in controls. Inflammatory response (neurogenic plasma extravasation) induced by xylene was found to be suppressed only in the offspring of the pregnant rats treated with high dose of capsaicin (50 mg/kg s.c.) in either single or multiple injection on day 15 of gestation Degeneration of both large (A-type) and small (B-type) dorsal root ganglion cells were also found in these same groups of animals. In adult capsaicin treated rats (20 mg/kg s.c.), the hot plate and paw pressure pain thresholds were significantly elevated at 0.5 hr after capsaicin injection and return to normal level within 1-5 days. Neurogenic plasma extravasation in the adult capsaicin treated rats was only 60% of that of controls, 1-2 hr. after injection of capsaicin. Morphological change was also detected within 1-2 hr after treatment in both large (A-type) and small (B-type) dorsal root ganglion cells of adult capsaicin treated rats. The recovery of nociception in adult capsaicin treated rats might be resulted from compensation by the remaining intact ganglion cells. This compensation probably occurred in prenatally capsaicin treated rats.
Description
Physiology (Mahidol University 1987)
Degree Name
Master of Science
Degree Level
Master's degree
Degree Department
Faculty of Science
Degree Discipline
Physiology
Degree Grantor(s)
Mahidol University