Antidementia drugs and nursing home placement: a systematic review and meta-analysis
Issued Date
2026-01-01
Resource Type
ISSN
18787649
eISSN
18787657
Scopus ID
2-s2.0-105027553210
Pubmed ID
41528688
Journal Title
European Geriatric Medicine
Rights Holder(s)
SCOPUS
Bibliographic Citation
European Geriatric Medicine (2026)
Suggested Citation
Rattanatanyapat P., Suan-ek P., Saokaew S., Phisalprapa P., Mongkhon P. Antidementia drugs and nursing home placement: a systematic review and meta-analysis. European Geriatric Medicine (2026). doi:10.1007/s41999-025-01398-3 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/114565
Title
Antidementia drugs and nursing home placement: a systematic review and meta-analysis
Author's Affiliation
Corresponding Author(s)
Other Contributor(s)
Abstract
Aim: This study aimed to investigate the effects of antidementia drugs (ADDs), including cholinesterase inhibitors (CEIs) and memantine, on nursing home placement (NHP) among individuals with dementia. Findings: ADDs may be associated with a lower risk of NHP, with a 57% reduction in Alzheimer’s disease and a 16% reduction in mixed-type dementia. There were no significant difference in NHP risk between donepezil and rivastigmine, or between donepezil and galantamine, or combining CEIs with memantine and CEIs monotherapy. Message: ADDs are associated with a reduced risk of NHP; however, future trials or well-designed studies are needed to understand the reasons for this association and to determine whether it is causal.