Reduced Red Blood Cell Deformability in Vivax Malaria
Issued Date
2025-03-15
Resource Type
ISSN
00221899
eISSN
15376613
Scopus ID
2-s2.0-105000329280
Pubmed ID
39374370
Journal Title
Journal of Infectious Diseases
Volume
231
Issue
3
Start Page
e566
End Page
e569
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Infectious Diseases Vol.231 No.3 (2025) , e566-e569
Suggested Citation
Rathnam J.T.T., Grigg M.J., Dondorp A.M., William T., Rajasekhar M., Rajahram G., Simpson J.A., Barber B.E., Anstey N.M. Reduced Red Blood Cell Deformability in Vivax Malaria. Journal of Infectious Diseases Vol.231 No.3 (2025) , e566-e569. e569. doi:10.1093/infdis/jiae490 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/108495
Title
Reduced Red Blood Cell Deformability in Vivax Malaria
Author's Affiliation
Corresponding Author(s)
Other Contributor(s)
Abstract
Reduced deformability of both infected and uninfected red blood cells (RBCs) contributes to pathogenesis in Plasmodium falciparum malaria. Whole-blood RBC deformability (RBC-D) is not well characterized in Plasmodium vivax malaria. We used a laser-assisted optical rotational cell analyzer to measure the RBC-D in fresh whole-blood samples from Malaysian patients with vivax malaria (n = 25). Deformability of whole-blood RBCs, the vast majority of which were uninfected, was reduced in vivax malaria compared with controls (n = 15), though not to the same degree as in falciparum malaria (n = 90). Reduced RBC-D may contribute to the pathogenesis of vivax malaria, including splenic retention of uninfected RBCs.