Lower extremity osseointegration for amputees with diabetes mellitus and vascular disease
Issued Date
2026-01-01
Resource Type
eISSN
25742167
Scopus ID
2-s2.0-105034304424
Journal Title
Ota International
Volume
9
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Ota International Vol.9 No.1 (2026)
Suggested Citation
Hoellwarth J.S., Yu L.Y.C., DeSena T.D., Wongcharoenwatana J., Reif T.J., Rozbruch S.R. Lower extremity osseointegration for amputees with diabetes mellitus and vascular disease. Ota International Vol.9 No.1 (2026). doi:10.1097/OI9.0000000000000472 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/116043
Title
Lower extremity osseointegration for amputees with diabetes mellitus and vascular disease
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Abstract
Objective: – The aim of this study was to describe outcomes of osseointegration in amputees with diabetes mellitus (DM) and/or peripheral vascular disease (PVD).Design: – This was a case series.Setting: – The study was conducted at an urban tertiary referral academic medical center.Patients/Participants: – Five patients (1 with DM, 3 with PVD, 1 with both; 4 transtibial, 1 transfemoral) with a follow-up duration of 4.1 ± 0.3 (3.6–4.3) years were included.Intervention: – Revision amputation with press-fit osseointegration implant insertion was performed.Main Outcome Measurements: – Primary outcomes included adverse events requiring nonsurgical or surgical intervention. Secondary outcomes included patient-reported outcome measures (PROMs) and mobility performance.Results: – No patients experienced implant loosening, periprosthetic fracture, procedure-related systemic complications, or death. Three patients received additional surgery: one had osteomyelitis, prompting debridement after 9 months; 2 underwent refashioning to reduce redundant skin around the portal site at 4 years. All PROMs improved significantly. All patients improved by at least one K-level.Conclusion: – Osseointegration appears safe to consider for appropriately selected patients with DM and/or PVD. Only one patient had an infection, requiring surgical debridement. The 2 refashioning cases were not infected and may have been avoidable with more aggressive tissue reduction at index surgery. No deaths or systemic complications occurred. Conscientious use and study of osseointegration may help optimize rehabilitation for amputees with DM and/or PVD.