Effect of vitamin D on lung function assessed by forced oscillation technique in asthmatic children with vitamin D deficiency: A randomized double-blind placebo-controlled trial
Issued Date
2022-03-01
Resource Type
ISSN
0125877X
eISSN
22288694
Scopus ID
2-s2.0-85088480186
Pubmed ID
31837209
Journal Title
Asian Pacific Journal of Allergy and Immunology
Volume
40
Issue
1
Start Page
22
End Page
30
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology Vol.40 No.1 (2022) , 22-30
Suggested Citation
Swangtrakul N., Manuyakorn W., Mahachoklertwattana P., Kiewngam P., Sasisakulporn C., Jotikasthira W., Kamchaisatian W., Benjaponpitak S. Effect of vitamin D on lung function assessed by forced oscillation technique in asthmatic children with vitamin D deficiency: A randomized double-blind placebo-controlled trial. Asian Pacific Journal of Allergy and Immunology Vol.40 No.1 (2022) , 22-30. 30. doi:10.12932/AP-010519-0553 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85021
Title
Effect of vitamin D on lung function assessed by forced oscillation technique in asthmatic children with vitamin D deficiency: A randomized double-blind placebo-controlled trial
Author's Affiliation
Other Contributor(s)
Abstract
Background: The role of vitamin D and asthma in pulmonary function changes showed conflicting result. Objective: To evaluate if vitamin D treatment would improve lung function assessed by forced oscillation technique (FOT) in vitamin D deficient asthmatic children. Methods: A randomized double-blind placebo-controlled trial was performed in children, aged 3-18 years with well controlled asthma. Serum total 25(OH)D and FOT parameters including respiratory resistance at 5 Hz (R5), at 20 Hz (R20), respiratory reactance at 5 Hz (X5) and area of reactance (ALX), resonance frequency (Fres) were evaluated at baseline, 1 month and 3 months. Vitamin D deficient patients (serum total 25(OH)D < 20 ng/ml) were randomized to receive treatment with vitamin D2 (tVDD) or placebo (pVDD). Non-vitamin D deficient patients (nVDD) received placebo as a control group. Results: A total of 84 children were recruited, 43 patients in nVDD group, 20 in tVDD group and 21 in pVDD group. There were no significant differences in age, sex, height and weight among groups. There were no significant differences of FOT parameters among groups at all visits. There was a trend toward decrease in R5/R20 from baseline to 1 month and 3 months visit in all groups, but the statistically significant improvement was observed only in nVDD group. Serum 25(OH)D showed no correlation with % predicted of FOT measures. Conclusion: Vitamin D treatment in asthmatic children who had vitamin D deficiency may have no short term beneficial effect on pulmonary function assessed by FOT. Vitamin D supplementation in all asthmatic patient needs further study.