Early Autonomic Dysfunction in Traumatic Brain Injury: An Article Review on the Impact on Multiple Organ Dysfunction
Issued Date
2025-01-01
Resource Type
eISSN
20770383
Scopus ID
2-s2.0-85216116646
Journal Title
Journal of Clinical Medicine
Volume
14
Issue
2
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Clinical Medicine Vol.14 No.2 (2025)
Suggested Citation
Wongsripuemtet P., Ohnuma T., Minic Z., Vavilala M.S., Miller J.B., Laskowitz D.T., Meurer W.J., Hu X., Korley F.K., Sheng H., Krishnamoorthy V. Early Autonomic Dysfunction in Traumatic Brain Injury: An Article Review on the Impact on Multiple Organ Dysfunction. Journal of Clinical Medicine Vol.14 No.2 (2025). doi:10.3390/jcm14020557 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/103136
Title
Early Autonomic Dysfunction in Traumatic Brain Injury: An Article Review on the Impact on Multiple Organ Dysfunction
Author's Affiliation
Siriraj Hospital
University of Michigan Medical School
Henry Ford Health System
University of Rijeka
University of Michigan, Ann Arbor
Woodruff Health Sciences Center
Wayne State University School of Medicine
University of Washington
Duke University School of Medicine
Max Harry Weil Institute for Critical Care Research and Innovation
University of Michigan Medical School
Henry Ford Health System
University of Rijeka
University of Michigan, Ann Arbor
Woodruff Health Sciences Center
Wayne State University School of Medicine
University of Washington
Duke University School of Medicine
Max Harry Weil Institute for Critical Care Research and Innovation
Corresponding Author(s)
Other Contributor(s)
Abstract
Background/Objectives: Traumatic brain injury (TBI) is a complex condition and a leading cause of injury-related disability and death, with significant impacts on patient outcomes. Extracranial organ involvement plays a critical role in the outcome of patients following TBI. Method: This review aims to provide a comprehensive overview of the pathophysiology, clinical presentation, and challenges in diagnosing patients with autonomic dysfunction after TBI. The databases used in this review include PubMed/MEDLINE, Cochrane Central Register, and Scopus. Results: Of 172 articles identified for screening, 98 were ultimately included in the review. Conclusion: This review summarized the current evidence on the pathophysiology, clinical presentation, and diagnosis of early autonomic dysfunction. It also emphasizes the effects of autonomic dysfunction on end-organ damage. These insights aim to guide clinicians and researchers toward improving the care for and understanding of autonomic dysfunction in TBI patients, while underscoring the need for further research in this area.