Plectranthus Species with Anti-Inflammatory and Analgesic Potential: A Systematic Review on Ethnobotanical and Pharmacological Findings
Issued Date
2023-08-01
Resource Type
eISSN
14203049
Scopus ID
2-s2.0-85167755117
Pubmed ID
37570622
Journal Title
Molecules
Volume
28
Issue
15
Rights Holder(s)
SCOPUS
Bibliographic Citation
Molecules Vol.28 No.15 (2023)
Suggested Citation
Barbosa M.d.O., Wilairatana P., Leite G.M.d.L., Delmondes G.d.A., Silva L.Y.S.d., Júnior S.C.A., Dantas L.B.R., Bezerra D.S., Beltrão I.C.S.L.d., Dias D.d.Q., Ribeiro-Filho J., Felipe C.F.B., Coutinho H.D.M., Menezes I.R.A.d., Kerntopf Mendonça M.R. Plectranthus Species with Anti-Inflammatory and Analgesic Potential: A Systematic Review on Ethnobotanical and Pharmacological Findings. Molecules Vol.28 No.15 (2023). doi:10.3390/molecules28155653 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/88826
Title
Plectranthus Species with Anti-Inflammatory and Analgesic Potential: A Systematic Review on Ethnobotanical and Pharmacological Findings
Other Contributor(s)
Abstract
The use of medicinal plants to treat inflammatory conditions and painful processes has attracted the attention of scientists and health professionals due to the evidence that natural products can promote significant therapeutic benefits associated with fewer adverse effects compared to conventional anti-inflammatory drugs. The genus Plectranthus is composed of various plants with pharmacological potential, which are used to treat various diseases in traditional communities worldwide. The present study systematically reviewed Plectranthus species with anti-inflammatory and analgesic potential. To this end, a systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. The search was conducted on the following databases: PubMed, ScienceDirect, SciVerse Scopus, and Web of Science. Different combinations of search terms were used to ensure more excellent article coverage. After the selection, a total of 45 articles were included in this review. This study identified twelve Plectranthus species indicated for the treatment of different inflammatory conditions, such as wounds, fever, bronchitis, abscess, asthma, hepatitis, labyrinthitis, tonsillitis, and uterine inflammation. The indications for pain conditions included headache, sore throat, heartburn, menstrual cramp, colic, toothache, stomachache, migraine, chest pain, abdominal pain, local pain, labor pain, and recurring pain. Among the listed species, ten plants were found to be used according to traditional knowledge, although only four of them have been experimentally studied. When assessing the methodological quality of preclinical in vivo assays, most items presented a risk of bias. The SR results revealed the existence of different Plectranthus species used to treat inflammation and pain. The results of this systematic review indicate that Plectranthus species have the potential to be used in the treatment of diseases with an inflammatory component, as well as in the management of pain. However, given the risk of biases, the experimental analysis of these species through preclinical testing is crucial for their safe and effective use.