Building a Synthetic Cell Together
Issued Date
2025-12-01
Resource Type
eISSN
20411723
Scopus ID
2-s2.0-105013263823
Pubmed ID
40796565
Journal Title
Nature Communications
Volume
16
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Nature Communications Vol.16 No.1 (2025)
Suggested Citation
Giaveri S., Abil Z., Kohyama S., Fu M., Levrier A., Adamala K., Chinantuya W., Dekker C., Deng N., Fredens J., Hagino K., Jahnke K., Li X., Lindner A.B., Liu C., Majumder S., Noireaux V., Schwille P., Westensee I.N. Building a Synthetic Cell Together. Nature Communications Vol.16 No.1 (2025). doi:10.1038/s41467-025-62778-8 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/111789
Title
Building a Synthetic Cell Together
Author's Affiliation
The University of Tokyo
University of Minnesota Twin Cities
Shanghai Jiao Tong University
University of Wisconsin-Madison
Sorbonne Université
Aarhus Universitet
University of Washington School of Medicine
College of Science and Engineering
Queensland University of Technology
Herbert Wertheim College of Engineering
NUS Yong Loo Lin School of Medicine
Shenzhen Institute of Advanced Technology
Harvard John A. Paulson School of Engineering and Applied Sciences
Max-Planck-Institut für Biochemie
Faculty of Science, Mahidol University
Max Planck Institute for Terrestrial Microbiology
Vidyasirimedhi Institute of Science and Technology
Department of Bionanoscience, TU Delft
Ri.MED Foundation
University of Minnesota Twin Cities
Shanghai Jiao Tong University
University of Wisconsin-Madison
Sorbonne Université
Aarhus Universitet
University of Washington School of Medicine
College of Science and Engineering
Queensland University of Technology
Herbert Wertheim College of Engineering
NUS Yong Loo Lin School of Medicine
Shenzhen Institute of Advanced Technology
Harvard John A. Paulson School of Engineering and Applied Sciences
Max-Planck-Institut für Biochemie
Faculty of Science, Mahidol University
Max Planck Institute for Terrestrial Microbiology
Vidyasirimedhi Institute of Science and Technology
Department of Bionanoscience, TU Delft
Ri.MED Foundation
Corresponding Author(s)
Other Contributor(s)
Abstract
Synthetic cells (SynCells) are artificial constructs designed to mimic cellular functions, offering insights into fundamental biology, as well as promising impact in the fields of medicine, biotechnology, and bioengineering. Achieving a functional SynCell from the bottom up, i.e. by assembling it from molecular components, requires a global collaboration to overcome the many challenges of engineering and assembling life-like modules while addressing biosafety, equity, and ethical concerns in order to guide responsible innovation. Here, we highlight major scientific hurdles, such as the integration of functional modules by ensuring compatibility across diverse synthetic subsystems, and we propose strategies to advance the field.