The combined tumour-based Fascin/Snail and stromal periostin reveals the effective prognosis prediction in colorectal cancer patients
Issued Date
2024-01-01
Resource Type
eISSN
19326203
Scopus ID
2-s2.0-85197169014
Pubmed ID
38935747
Journal Title
PloS one
Volume
19
Issue
6
Rights Holder(s)
SCOPUS
Bibliographic Citation
PloS one Vol.19 No.6 (2024) , e0304666
Suggested Citation
Jirapongwattana N., Thongchot S., Pongpaibul A., Trakarnsanga A., Quinn J., Thuwajit P., Thuwajit C., Edwards J. The combined tumour-based Fascin/Snail and stromal periostin reveals the effective prognosis prediction in colorectal cancer patients. PloS one Vol.19 No.6 (2024) , e0304666. doi:10.1371/journal.pone.0304666 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/99596
Title
The combined tumour-based Fascin/Snail and stromal periostin reveals the effective prognosis prediction in colorectal cancer patients
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Corresponding Author(s)
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Abstract
Colorectal cancer (CRC) is the third most common malignancy cause of cancer-related mortality worldwide. Epithelial-mesenchymal transition (EMT) promotes cancer metastasis and a tumour-based Glasgow EMT score was associated with adverse clinical features and poor prognosis. In this study, the impact of using the established five tumour-based EMT markers consisting of E-cadherin (E-cad), β-catenin (β-cat), Snail, Zeb-1, and Fascin in combination with the stromal periostin (PN) on the prediction of CRC patients' prognosis were invesigated. Formalin-fixed paraffin-embedded tissues of 202 CRC patients were studies the expressions of E-cad, β-cat, Snail, Zeb-1, Fascin, and PN by immunohistochemistry. Individually, cytoplasmic Fascin (Fc), cytoplasmic Snail (Sc), nuclear Snail (Sn), stromal Snail (Ss), and stromal PN (Ps) were significantly associated with reduced survival. A combination of Ps with Fc, Fs, and Sn was observed in 2 patterns including combined Fc, Fs, and Ps (FcFsPs) and Fc, Sn, and Ps (FcSnPs). These combinations enhanced the prognostic power compared to individual EMT markers and were independent prognostic markers. As the previously established scoring method required five markers and stringent criteria, its clinical use might be limited. Therefore, using these novel combined prognostic markers, either FcFsPs or FcSnPs, may be useful in predicting CRC patient outcomes.