Cytotoxic compounds from Goniothalamus repevensis Pierre ex Finet & Gagnep
7
Issued Date
2022-01-01
Resource Type
ISSN
15131874
Scopus ID
2-s2.0-85129666791
Journal Title
ScienceAsia
Volume
48
Issue
4
Start Page
429
End Page
433
Rights Holder(s)
SCOPUS
Bibliographic Citation
ScienceAsia Vol.48 No.4 (2022) , 429-433
Suggested Citation
Chanakul W., Reutrakul V., Kuhakarn C., Bunteang S., Piyachaturawat P., Suksen K., Hongthong S., Thanasansurapong S., Nuntasaen N. Cytotoxic compounds from Goniothalamus repevensis Pierre ex Finet & Gagnep. ScienceAsia Vol.48 No.4 (2022) , 429-433. 433. doi:10.2306/SCIENCEASIA1513-1874.2022.059 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/86649
Title
Cytotoxic compounds from Goniothalamus repevensis Pierre ex Finet & Gagnep
Other Contributor(s)
Abstract
Phytochemical investigation of the methanol extract of the leaves and twigs of Goniothalamus repevensis led to the isolation of five known compounds including two styryl lactones; (–)-goniodiol-7-monoacetate (1) and (–)-goniodiol diacetate (2) as well as three aristolactam alkaloids; piperolactam C (3), aristolactam A III (4), and aristolactam B III (5). The structure determination was established by various spectroscopic methods and by comparison with the literature data. Cytotoxic activity against a panel of mammalian cancerous cell lines of compounds 1–4 was investigated. Piperolactam C (3) was found to be active in all tested cell lines with IC50 values in the range of 3.30–64.6 µM. (–)-Goniodiol-7-monoacetate (1) exhibited cytotoxic activity only against ASK cells with IC50 value of 10.28 µM. Having been isolated as a major component, compound 1 can be considered chemotaxonomic significance for G. repevensis.