Dextran-Based Nanoparticles for Encapsulation of Ciprofloxacin
Issued Date
2022-02-04
Resource Type
ISSN
17426588
eISSN
17426596
Scopus ID
2-s2.0-85124966526
Journal Title
Journal of Physics: Conference Series
Volume
2175
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Physics: Conference Series Vol.2175 No.1 (2022)
Suggested Citation
Watcharadulyarat N., Rattanatayarom M., Ruangsawasdi N., Hongdilokkul N., Patikarnmonthon N. Dextran-Based Nanoparticles for Encapsulation of Ciprofloxacin. Journal of Physics: Conference Series Vol.2175 No.1 (2022). doi:10.1088/1742-6596/2175/1/012006 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/86926
Title
Dextran-Based Nanoparticles for Encapsulation of Ciprofloxacin
Author's Affiliation
Other Contributor(s)
Abstract
Key success for regenerative endodontics is an effective removal of bacteria inside the root canal during the treatment. Ciprofloxacin (CIP) is one of the triple antibiotics commonly used as the root canal medicament. However, the rapid clearance of antibiotics causes bacterial reinfection. Nanoparticles (NPs) provide an alternative approach for antibiotics delivery system to improve the drug stability and release control. In the previous study, modified dextran was successfully formed the ester linkage with vinyl decanoate via lipase-catalyzed transesterification. The amphiphilic dextran, dextran-decanoate (Dex-D), has been synthesized with the degree of substitution of 83-88% and were applied for CIP-loaded nanoparticles. The suitable technique for producing antibiotic carriers considering by size, shape, and drug encapsulation efficiency was investigated in this work. The preparation methods were compared between nanoprecipitation and solid-in-oil-in-water (s/o/w) ion pairing technique. We found that the obtained Dex-D nanoparticles had stable monodispersed with spherical shape in both techniques. However, Dex-D nanoparticles formed by s/o/w ion pairing technique provided smaller size with better encapsulation efficiency. The antimicrobial activity of CIP-loaded Dex-D nanoparticles against oral pathogens showed satisfactory outcome with the MIC equal to 0.7 µg/mL. Also, the compatibility of nanoparticles and dental stem cells was observed in this work.