Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis
Issued Date
2024-01-01
Resource Type
ISSN
00029165
eISSN
19383207
Scopus ID
2-s2.0-85184683244
Pubmed ID
37890672
Journal Title
American Journal of Clinical Nutrition
Volume
119
Issue
1
Start Page
221
End Page
231
Rights Holder(s)
SCOPUS
Bibliographic Citation
American Journal of Clinical Nutrition Vol.119 No.1 (2024) , 221-231
Suggested Citation
Monangi N.K., Xu H., Fan Y.M., Khanam R., Khan W., Deb S., Pervin J., Price J.T., Kaur L., Villar J., McGready R., Barros F.C., Victora C.G., Munim S., Papageorgh A.T., Ochieng R., Craik R., Barososio H.C., Berkley J.A., Carvalho M., Ismail L.C., Lambert A., Norris S.A., Tshivuila-Matela C.O., Nosten F., Uauy R., Bhutta Z.A., Kennedy S., Al Mahmud A., Thanh L.Q., Care A., Landero J.A., Combs G.F., Belling E., Chappell J., Chen J., Kong F., Lacher C., Ahmed S., Chowdhury N.H., Rahman S., Kabir F., Nisar I., Hotwani A., Mehmood U., Nizar A., Khalid J., Dhingra U., Dutta A., Ali S.M., Aftab F., Juma M.H., Rahman M., Ahmed T., Islam M.M., Vwalika B., Musonda P., Ashorn U., Maleta K., Hallman M., Goodfellow L., Gupta J.K., Alfirevic A., Murphy S.K., Rand L., Ryckman K.K., Murray J.C., Bahl R., Litch J.A., Baruch-Gravett C., Sopory S., Chandra Mouli Natchu U., Kumar P.V., Kumari N., Thiruvengadam R., Singh A.K., Kumar P., Alfirevic Z., Baqui A.H., Bhatnagar S., Hirst J.E., Hoyo C., Jehan F., Jelliffe-Pawlowski L., Rahman A., Roth D.E., Sazawal S., Stringer J.S.A., Ashorn P., Zhang G., Muglia L.J. Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis. American Journal of Clinical Nutrition Vol.119 No.1 (2024) , 221-231. 231. doi:10.1016/j.ajcnut.2023.10.011 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/97279
Title
Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis
Author(s)
Monangi N.K.
Xu H.
Fan Y.M.
Khanam R.
Khan W.
Deb S.
Pervin J.
Price J.T.
Kaur L.
Villar J.
McGready R.
Barros F.C.
Victora C.G.
Munim S.
Papageorgh A.T.
Ochieng R.
Craik R.
Barososio H.C.
Berkley J.A.
Carvalho M.
Ismail L.C.
Lambert A.
Norris S.A.
Tshivuila-Matela C.O.
Nosten F.
Uauy R.
Bhutta Z.A.
Kennedy S.
Al Mahmud A.
Thanh L.Q.
Care A.
Landero J.A.
Combs G.F.
Belling E.
Chappell J.
Chen J.
Kong F.
Lacher C.
Ahmed S.
Chowdhury N.H.
Rahman S.
Kabir F.
Nisar I.
Hotwani A.
Mehmood U.
Nizar A.
Khalid J.
Dhingra U.
Dutta A.
Ali S.M.
Aftab F.
Juma M.H.
Rahman M.
Ahmed T.
Islam M.M.
Vwalika B.
Musonda P.
Ashorn U.
Maleta K.
Hallman M.
Goodfellow L.
Gupta J.K.
Alfirevic A.
Murphy S.K.
Rand L.
Ryckman K.K.
Murray J.C.
Bahl R.
Litch J.A.
Baruch-Gravett C.
Sopory S.
Chandra Mouli Natchu U.
Kumar P.V.
Kumari N.
Thiruvengadam R.
Singh A.K.
Kumar P.
Alfirevic Z.
Baqui A.H.
Bhatnagar S.
Hirst J.E.
Hoyo C.
Jehan F.
Jelliffe-Pawlowski L.
Rahman A.
Roth D.E.
Sazawal S.
Stringer J.S.A.
Ashorn P.
Zhang G.
Muglia L.J.
Xu H.
Fan Y.M.
Khanam R.
Khan W.
Deb S.
Pervin J.
Price J.T.
Kaur L.
Villar J.
McGready R.
Barros F.C.
Victora C.G.
Munim S.
Papageorgh A.T.
Ochieng R.
Craik R.
Barososio H.C.
Berkley J.A.
Carvalho M.
Ismail L.C.
Lambert A.
Norris S.A.
Tshivuila-Matela C.O.
Nosten F.
Uauy R.
Bhutta Z.A.
Kennedy S.
Al Mahmud A.
Thanh L.Q.
Care A.
Landero J.A.
Combs G.F.
Belling E.
Chappell J.
Chen J.
Kong F.
Lacher C.
Ahmed S.
Chowdhury N.H.
Rahman S.
Kabir F.
Nisar I.
Hotwani A.
Mehmood U.
Nizar A.
Khalid J.
Dhingra U.
Dutta A.
Ali S.M.
Aftab F.
Juma M.H.
Rahman M.
Ahmed T.
Islam M.M.
Vwalika B.
Musonda P.
Ashorn U.
Maleta K.
Hallman M.
Goodfellow L.
Gupta J.K.
Alfirevic A.
Murphy S.K.
Rand L.
Ryckman K.K.
Murray J.C.
Bahl R.
Litch J.A.
Baruch-Gravett C.
Sopory S.
Chandra Mouli Natchu U.
Kumar P.V.
Kumari N.
Thiruvengadam R.
Singh A.K.
Kumar P.
Alfirevic Z.
Baqui A.H.
Bhatnagar S.
Hirst J.E.
Hoyo C.
Jehan F.
Jelliffe-Pawlowski L.
Rahman A.
Roth D.E.
Sazawal S.
Stringer J.S.A.
Ashorn P.
Zhang G.
Muglia L.J.
Author's Affiliation
Kamuzu University of Health Sciences
Medical Research Center Oulu
Mahidol Oxford Tropical Medicine Research Unit
St. John's Research Institute
Duke University Medical Center
Jean Mayer USDA Human Nutrition Research Center on Aging
University of Zambia School of Medicine
University of Zambia
University of Sharjah
Wellcome Trust Research Laboratories Nairobi
The Aga Khan University Medical College
The Aga Khan University
UCSF School of Medicine
London School of Hygiene & Tropical Medicine
Cincinnati Children's Hospital Medical Center
Hospital for Sick Children University of Toronto
Organisation Mondiale de la Santé
Green Templeton College
University of Cincinnati
University of Iowa
Universidade Catolica de Pelotas
Liverpool School of Tropical Medicine
University of Liverpool
UNC School of Medicine
University of Cincinnati College of Medicine
University of Toronto
University of the Witwatersrand, Johannesburg
Universidade Federal de Pelotas
Tampere University
International Centre for Diarrhoeal Disease Research Bangladesh
Nuffield Department of Medicine
University Hospital of Tampere
Johns Hopkins Bloomberg School of Public Health
USDA ARS Grand Forks Human Nutrition Research Center
NC State University
Burroughs Wellcome Fund
University of Oxford Medical Sciences Division
Inter University Accelerator Centre India
Translational Health Science and Technology Institute (THSTI)
Center for Public Health Kinetics
Projahnmo Research Foundation
Tu Du Hospital
Lynnwood
Center for Public Health Kinetics
Medical Research Center Oulu
Mahidol Oxford Tropical Medicine Research Unit
St. John's Research Institute
Duke University Medical Center
Jean Mayer USDA Human Nutrition Research Center on Aging
University of Zambia School of Medicine
University of Zambia
University of Sharjah
Wellcome Trust Research Laboratories Nairobi
The Aga Khan University Medical College
The Aga Khan University
UCSF School of Medicine
London School of Hygiene & Tropical Medicine
Cincinnati Children's Hospital Medical Center
Hospital for Sick Children University of Toronto
Organisation Mondiale de la Santé
Green Templeton College
University of Cincinnati
University of Iowa
Universidade Catolica de Pelotas
Liverpool School of Tropical Medicine
University of Liverpool
UNC School of Medicine
University of Cincinnati College of Medicine
University of Toronto
University of the Witwatersrand, Johannesburg
Universidade Federal de Pelotas
Tampere University
International Centre for Diarrhoeal Disease Research Bangladesh
Nuffield Department of Medicine
University Hospital of Tampere
Johns Hopkins Bloomberg School of Public Health
USDA ARS Grand Forks Human Nutrition Research Center
NC State University
Burroughs Wellcome Fund
University of Oxford Medical Sciences Division
Inter University Accelerator Centre India
Translational Health Science and Technology Institute (THSTI)
Center for Public Health Kinetics
Projahnmo Research Foundation
Tu Du Hospital
Lynnwood
Center for Public Health Kinetics
Corresponding Author(s)
Other Contributor(s)
Abstract
Background: Copper (Cu), an essential trace mineral regulating multiple actions of inflammation and oxidative stress, has been implicated in risk for preterm birth (PTB). Objectives: This study aimed to determine the association of maternal Cu concentration during pregnancy with PTB risk and gestational duration in a large multicohort study including diverse populations. Methods: Maternal plasma or serum samples of 10,449 singleton live births were obtained from 18 geographically diverse study cohorts. Maternal Cu concentrations were determined using inductively coupled plasma mass spectrometry. The associations of maternal Cu with PTB and gestational duration were analyzed using logistic and linear regressions for each cohort. The estimates were then combined using meta-analysis. Associations between maternal Cu and acute-phase reactants (APRs) and infection status were analyzed in 1239 samples from the Malawi cohort. Results: The maternal prenatal Cu concentration in our study samples followed normal distribution with mean of 1.92 μg/mL and standard deviation of 0.43 μg/mL, and Cu concentrations increased with gestational age up to 20 wk. The random-effect meta-analysis across 18 cohorts revealed that 1 μg/mL increase in maternal Cu concentration was associated with higher risk of PTB with odds ratio of 1.30 (95% confidence interval [CI]: 1.08, 1.57) and shorter gestational duration of 1.64 d (95% CI: 0.56, 2.73). In the Malawi cohort, higher maternal Cu concentration, concentrations of multiple APRs, and infections (malaria and HIV) were correlated and associated with greater risk of PTB and shorter gestational duration. Conclusions: Our study supports robust negative association between maternal Cu and gestational duration and positive association with risk for PTB. Cu concentration was strongly correlated with APRs and infection status suggesting its potential role in inflammation, a pathway implicated in the mechanisms of PTB. Therefore, maternal Cu could be used as potential marker of integrated inflammatory pathways during pregnancy and risk for PTB.