Mechanisms, Anti-Quorum-Sensing Actions, and Clinical Trials of Medicinal Plant Bioactive Compounds against Bacteria: A Comprehensive Review
Issued Date
2022-03-01
Resource Type
eISSN
14203049
Scopus ID
2-s2.0-85125205422
Pubmed ID
35268585
Journal Title
Molecules
Volume
27
Issue
5
Rights Holder(s)
SCOPUS
Bibliographic Citation
Molecules Vol.27 No.5 (2022)
Suggested Citation
Bouyahya A., Chamkhi I., Balahbib A., Rebezov M., Shariati M.A., Wilairatana P., Mubarak M.S., Benali T., El Omari N. Mechanisms, Anti-Quorum-Sensing Actions, and Clinical Trials of Medicinal Plant Bioactive Compounds against Bacteria: A Comprehensive Review. Molecules Vol.27 No.5 (2022). doi:10.3390/molecules27051484 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/83807
Title
Mechanisms, Anti-Quorum-Sensing Actions, and Clinical Trials of Medicinal Plant Bioactive Compounds against Bacteria: A Comprehensive Review
Author's Affiliation
Faculty of Tropical Medicine, Mahidol University
Mohammed VI Polytechnic University
Moscow State University of Technologies and Management
Faculté de Médecine et de Pharmacie de Rabat
Prokhorov General Physics Institute of the Russian Academy of Sciences
The University of Jordan
Institut Scientifique
Université Cadi Ayyad
Faculté des Sciences Rabat
V. M. Gorbatov Federal Research Center for Food Systems
Mohammed VI Polytechnic University
Moscow State University of Technologies and Management
Faculté de Médecine et de Pharmacie de Rabat
Prokhorov General Physics Institute of the Russian Academy of Sciences
The University of Jordan
Institut Scientifique
Université Cadi Ayyad
Faculté des Sciences Rabat
V. M. Gorbatov Federal Research Center for Food Systems
Other Contributor(s)
Abstract
Bacterial strains have developed an ability to resist antibiotics via numerous mechanisms. Recently, researchers conducted several studies to identify natural bioactive compounds, particularly secondary metabolites of medicinal plants, such as terpenoids, flavonoids, and phenolic acids, as antibacterial agents. These molecules exert several mechanisms of action at different structural, cellular, and molecular levels, which could make them candidates or lead compounds for devel-oping natural antibiotics. Research findings revealed that these bioactive compounds can inhibit the synthesis of DNA and proteins, block oxidative respiration, increase membrane permeability, and decrease membrane integrity. Furthermore, recent investigations showed that some bacterial strains resist these different mechanisms of antibacterial agents. Researchers demonstrated that this resistance to antibiotics is linked to a microbial cell-to-cell communication system called quorum sensing (QS). Consequently, inhibition of QS or quorum quenching is a promising strategy to not only overcome the resistance problems but also to treat infections. In this respect, various bioactive molecules, including terpenoids, flavonoids, and phenolic acids, exhibit numerous anti-QS mechanisms via the inhibition of auto-inducer releases, sequestration of QS-mediated molecules, and deregulation of QS gene expression. However, clinical applications of these molecules have not been fully covered, which limits their use against infectious diseases. Accordingly, the aim of the present work was to discuss the role of the QS system in bacteria and its involvement in virulence and resistance to antibiotics. In addition, the present review summarizes the most recent and relevant literature pertaining to the anti-quorum sensing of secondary metabolites and its relationship to antibacterial activity.