Defining Criteria for Disease Activity States in Systemic Juvenile Idiopathic Arthritis Based on the Systemic Juvenile Arthritis Disease Activity Score
1
Issued Date
2024-01-01
Resource Type
ISSN
23265191
eISSN
23265205
Scopus ID
2-s2.0-85195592307
Pubmed ID
38682570
Journal Title
Arthritis and Rheumatology
Rights Holder(s)
SCOPUS
Bibliographic Citation
Arthritis and Rheumatology (2024)
Suggested Citation
Rosina S., Rebollo-Giménez A.I., Tarantola L., Pistorio A., Vyzhga Y., El Miedany Y., Lotfy H.M., Abu-Shady H., Eissa M., Osman N.S., Hassan W., Mahgoub M.Y., Fouad N.A., Mosa D.M., Adel Y., Mohamed S.E.M., Radwan A.R., Abu-Zaid M.H., Tabra S.A.A., Shalaby R.H., Nasef S.I., Khubchandani R., Khan A., Maldar N.P., Ozen S., Bayindir Y., Alsuweiti M., Alzyoud R., Almaaitah H., Vilaiyuk S., Lerkvaleekul B., Alexeeva E., Dvoryakovskaya T., Kriulin I., Bracaglia C., Pardeo M., De Benedetti F., Licciardi F., Montin D., Robasto F., Minoia F., Filocamo G., Rossano M., Simonini G., Marrani E., Abu-Rumeileh S., Kostik M.M., Belozerov K.E., Pal P., Bathia J.N., Katsicas M.M., Villarreal G., Marino A., Costi S., Sztajnbok F., Silva R.M., Maggio M.C., El-Ghoneimy D.H., El Owaidy R., Civino A., Diomeda F., Al-Mayouf S.M., Al-Sofyani F., Dāvidsone Z., Patrone E., Saad-Magalhães C., Consolaro A., Ravelli A. Defining Criteria for Disease Activity States in Systemic Juvenile Idiopathic Arthritis Based on the Systemic Juvenile Arthritis Disease Activity Score. Arthritis and Rheumatology (2024). doi:10.1002/art.42865 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/98832
Title
Defining Criteria for Disease Activity States in Systemic Juvenile Idiopathic Arthritis Based on the Systemic Juvenile Arthritis Disease Activity Score
Author(s)
Rosina S.
Rebollo-Giménez A.I.
Tarantola L.
Pistorio A.
Vyzhga Y.
El Miedany Y.
Lotfy H.M.
Abu-Shady H.
Eissa M.
Osman N.S.
Hassan W.
Mahgoub M.Y.
Fouad N.A.
Mosa D.M.
Adel Y.
Mohamed S.E.M.
Radwan A.R.
Abu-Zaid M.H.
Tabra S.A.A.
Shalaby R.H.
Nasef S.I.
Khubchandani R.
Khan A.
Maldar N.P.
Ozen S.
Bayindir Y.
Alsuweiti M.
Alzyoud R.
Almaaitah H.
Vilaiyuk S.
Lerkvaleekul B.
Alexeeva E.
Dvoryakovskaya T.
Kriulin I.
Bracaglia C.
Pardeo M.
De Benedetti F.
Licciardi F.
Montin D.
Robasto F.
Minoia F.
Filocamo G.
Rossano M.
Simonini G.
Marrani E.
Abu-Rumeileh S.
Kostik M.M.
Belozerov K.E.
Pal P.
Bathia J.N.
Katsicas M.M.
Villarreal G.
Marino A.
Costi S.
Sztajnbok F.
Silva R.M.
Maggio M.C.
El-Ghoneimy D.H.
El Owaidy R.
Civino A.
Diomeda F.
Al-Mayouf S.M.
Al-Sofyani F.
Dāvidsone Z.
Patrone E.
Saad-Magalhães C.
Consolaro A.
Ravelli A.
Rebollo-Giménez A.I.
Tarantola L.
Pistorio A.
Vyzhga Y.
El Miedany Y.
Lotfy H.M.
Abu-Shady H.
Eissa M.
Osman N.S.
Hassan W.
Mahgoub M.Y.
Fouad N.A.
Mosa D.M.
Adel Y.
Mohamed S.E.M.
Radwan A.R.
Abu-Zaid M.H.
Tabra S.A.A.
Shalaby R.H.
Nasef S.I.
Khubchandani R.
Khan A.
Maldar N.P.
Ozen S.
Bayindir Y.
Alsuweiti M.
Alzyoud R.
Almaaitah H.
Vilaiyuk S.
Lerkvaleekul B.
Alexeeva E.
Dvoryakovskaya T.
Kriulin I.
Bracaglia C.
Pardeo M.
De Benedetti F.
Licciardi F.
Montin D.
Robasto F.
Minoia F.
Filocamo G.
Rossano M.
Simonini G.
Marrani E.
Abu-Rumeileh S.
Kostik M.M.
Belozerov K.E.
Pal P.
Bathia J.N.
Katsicas M.M.
Villarreal G.
Marino A.
Costi S.
Sztajnbok F.
Silva R.M.
Maggio M.C.
El-Ghoneimy D.H.
El Owaidy R.
Civino A.
Diomeda F.
Al-Mayouf S.M.
Al-Sofyani F.
Dāvidsone Z.
Patrone E.
Saad-Magalhães C.
Consolaro A.
Ravelli A.
Author's Affiliation
Ain Shams University Children's Hospital
College of Medicine Alfaisal University
Ramathibodi Hospital
Bērnu klīniskā UniversItātes Slimnīca
Azienda Ospedaliera - Universitaria Città della Salute e della Scienza di Torino
Al-Minya University Hospital
King Hussein Medical Center, Amman
Ospedale Vito Fazzi
Institute of Child Health Kolkata
Fayoum University
Benha University
Università degli Studi di Genova
Università degli Studi di Firenze
Hacettepe Üniversitesi
Suez Canal University
Canterbury Christ Church University
Saint Petersburg State Pediatric Medical University
IRCCS Ospedale Pediatrico Bambino Gesù
Università degli Studi di Palermo
Istituto Giannina Gaslini
Sohag University
Università degli Studi di Torino
Mansoura University
Tanta University
Cairo University
Sechenov First Moscow State Medical University
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Universidade Estadual Paulista "Júlio de Mesquita Filho"
Universidade do Estado do Rio de Janeiro
Fundacion Hospital de Pediatria Professor Dr. Juan P. Garrahan
Assiut University
SRCC NH Children Hospital
National Medical Research Center of Children’s Health
ASST Pini-CTO
Meyer Children's Hospital IRCCS
College of Medicine Alfaisal University
Ramathibodi Hospital
Bērnu klīniskā UniversItātes Slimnīca
Azienda Ospedaliera - Universitaria Città della Salute e della Scienza di Torino
Al-Minya University Hospital
King Hussein Medical Center, Amman
Ospedale Vito Fazzi
Institute of Child Health Kolkata
Fayoum University
Benha University
Università degli Studi di Genova
Università degli Studi di Firenze
Hacettepe Üniversitesi
Suez Canal University
Canterbury Christ Church University
Saint Petersburg State Pediatric Medical University
IRCCS Ospedale Pediatrico Bambino Gesù
Università degli Studi di Palermo
Istituto Giannina Gaslini
Sohag University
Università degli Studi di Torino
Mansoura University
Tanta University
Cairo University
Sechenov First Moscow State Medical University
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Universidade Estadual Paulista "Júlio de Mesquita Filho"
Universidade do Estado do Rio de Janeiro
Fundacion Hospital de Pediatria Professor Dr. Juan P. Garrahan
Assiut University
SRCC NH Children Hospital
National Medical Research Center of Children’s Health
ASST Pini-CTO
Meyer Children's Hospital IRCCS
Corresponding Author(s)
Other Contributor(s)
Abstract
Objective: Our objective was to develop and validate cutoff values in the systemic Juvenile Arthritis Disease Activity Score 10 (sJADAS10) that distinguish the states of inactive disease (ID), minimal disease activity (MDA), moderate disease activity (MoDA), and high disease activity (HDA) in children with systemic juvenile idiopathic arthritis, based on subjective disease state assessment by the treating pediatric rheumatologist. Methods: The cutoff definition cohort was composed of 400 patients enrolled at 30 pediatric rheumatology centers in 11 countries. Using the subjective physician rating as an external criterion, six methods were applied to identify the cutoffs: mapping, calculation of percentiles of cumulative score distribution, the Youden index, 90% specificity, maximum agreement, and receiver operating characteristic curve analysis. Sixty percent of the patients were assigned to the definition cohort, and 40% were assigned to the validation cohort. Cutoff validation was conducted by assessing discriminative ability. Results: The sJADAS10 cutoffs that separated ID from MDA, MDA from MoDA, and MoDA from HDA were ≤2.9, ≤10, and >20.6, respectively. The cutoffs discriminated strongly among different levels of pain, between patients with and without morning stiffness, and among patients whose parents judged their disease status as remission or persistent activity or flare or were satisfied or not satisfied with current illness outcome. Conclusion: The sJADAS cutoffs revealed good metrologic properties in both definition and validation cohorts and are therefore suitable for use in clinical trials and routine practice.