Characteristics of culture-negative subclinical pulmonary tuberculosis: a single-center observation
Issued Date
2024-01-01
Resource Type
ISSN
1828695X
eISSN
20496958
Scopus ID
2-s2.0-85194429248
Journal Title
Multidisciplinary Respiratory Medicine
Volume
19
Rights Holder(s)
SCOPUS
Bibliographic Citation
Multidisciplinary Respiratory Medicine Vol.19 (2024)
Suggested Citation
Chansaengpetch S., Kaewlai R., Virojskulchai T., Jaroonpipatkul A., Chierakul N., Muangman N., Tongdee T., Tanomkiat W., Dissaneevate K., Bunman S., Ruangchira-Urai R., Dejnirattisai W., Dumavibhat N. Characteristics of culture-negative subclinical pulmonary tuberculosis: a single-center observation. Multidisciplinary Respiratory Medicine Vol.19 (2024). doi:10.5826/mrm.2024.955 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/98615
Title
Characteristics of culture-negative subclinical pulmonary tuberculosis: a single-center observation
Corresponding Author(s)
Other Contributor(s)
Abstract
Background: Little is known about culture-negative subclinical pulmonary tuberculosis (TB), and its diagnosis remains challenging. Therefore, this study aimed to identify the characteristics and the extent of disease associated with culture-negative subclinical pulmonary TB. Methods: This retrospective cohort study was conducted on immunocompetent individuals with subclinical pulmonary TB at a university hospital in Thailand from January 2014 to December 2019. Subclinical pulmonary TB was diagnosed based on the presence of radiographic abnormalities consistent with TB in the absence of TB symptoms. All subjects demonstrated significant improvement or resolution of radiographic abnormalities following the completion of treatment. At least two negative sputum cultures were needed to fulfill the definition of culture-negative pulmonary TB. Data were analyzed using univariate and multiple logistic regression analyses to determine the characteristics of those with culture-negative subclinical pulmonary TB compared to culturepositive ones. Results: Out of the 106 individuals identified with subclinical pulmonary TB, 84 met the criteria for inclusion in the analysis. The study found lower radiographic extent and increasing age were key attributes of culture-negative subclinical pulmonary TB. The odds ratios (95% confidence interval) were 7.18 (1.76 to 29.35) and 1.07 (1.01 to 1.13), respectively. They tend to have lower rates of bilateral involvement in both chest x-ray (8.5% vs. 32.0%, p=0.006) and computed tomography (15.4% vs. 42.9%, p=0.035). However, no other specific radiographic findings were identified. Conclusions: People with culture-negative subclinical pulmonary TB were likely to have less radiographic severity, reflecting early disease. Nevertheless, no radiographic patterns, except for unilaterality, were related to culture-negative subclinical pulmonary TB.