Conserved HSFA1-dependent chromatin dynamics drive heat stress responses in plants
Issued Date
2025-12-23
Resource Type
ISSN
26391856
eISSN
22111247
Scopus ID
2-s2.0-105025798669
Pubmed ID
41391150
Journal Title
Cell Reports
Volume
44
Issue
12
Rights Holder(s)
SCOPUS
Bibliographic Citation
Cell Reports Vol.44 No.12 (2025)
Suggested Citation
Yen M.J., Lin K.H., Thalimaraw L., Yang H.R., Boonyaves K., Cheng C.Y., Wu T.Y. Conserved HSFA1-dependent chromatin dynamics drive heat stress responses in plants. Cell Reports Vol.44 No.12 (2025). doi:10.1016/j.celrep.2025.116714 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/113732
Title
Conserved HSFA1-dependent chromatin dynamics drive heat stress responses in plants
Corresponding Author(s)
Other Contributor(s)
Abstract
Eukaryotic organisms remodel chromatin landscapes to regulate gene expression in response to environmental stress. In plants, heat stress (HS) induces widespread chromatin changes, yet the role of heat shock transcription factors (HSFs) in chromatin remodeling and their evolutionary conservation remains unclear. Using Marchantia polymorpha Mphsf mutants and Arabidopsis thaliana Athsfa1s mutants, we identify HSFA1 as a key regulator of HS-induced cis-regulatory element (CRE) accessibility, a mechanism conserved across land plants, mice, and humans. Gene regulatory network modeling reveals parallel transcription factor subnetworks, with MpWRKY10 and MpABI5B acting as indirect and negative HS regulators. We further showed that ABA modulates gene expression in an HSFA1-dependent manner without inducing chromatin remodeling. Finally, we develop a machine learning framework integrating chromatin accessibility and CRE information to predict gene expression across species, revealing stress-responsive regulatory logic at the transcriptional level. These findings provide insights into how TFs coordinate chromatin architecture to drive stress adaptation.