Clinical outcomes of combined cervical and transthoracic surgical approaches in patients with advanced thyroid cancer
Issued Date
2023-03-01
Resource Type
ISSN
10433074
eISSN
10970347
Scopus ID
2-s2.0-85144174192
Pubmed ID
36524701
Journal Title
Head and Neck
Volume
45
Issue
3
Start Page
547
End Page
554
Rights Holder(s)
SCOPUS
Bibliographic Citation
Head and Neck Vol.45 No.3 (2023) , 547-554
Suggested Citation
Shenson J.A., Zafereo M.E., Lee M., Contrera K.J., Feng L., Boonsripitayanon M., Gross N., Goepfert R., Maniakas A., Wang J.R., Grubbs L., Vaporciyan A., Hofstetter W., Swisher S., Mehran R., Rice D., Sepesi B., Antonoff M., Cabanillas M., Busaidy N., Dadu R., Silver N.L. Clinical outcomes of combined cervical and transthoracic surgical approaches in patients with advanced thyroid cancer. Head and Neck Vol.45 No.3 (2023) , 547-554. 554. doi:10.1002/hed.27260 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82675
Title
Clinical outcomes of combined cervical and transthoracic surgical approaches in patients with advanced thyroid cancer
Author's Affiliation
Other Contributor(s)
Abstract
Background: Advanced thyroid disease involving the mediastinum may be managed surgically with a combined transcervical and transthoracic approach. Contemporary analysis of this infrequently encountered cohort will aid the multidisciplinary team in personalizing treatment approaches. Methods: Retrospective review of patients undergoing combined transcervical and transthoracic surgery for thyroid cancer at a single high-volume institution from 1994 to 2015. Results: Thirty-eight patients with median age 59 years (range 28–76) underwent surgery without perioperative mortality. Most patients had primary disease. A majority had distant metastases outside the mediastinum but had locoregionally curable disease. Common complications were temporary (39%) and permanent (18%) hypoparathyroidism, and wound infection (13%). One-year overall survival was 84%; 1-year locoregional disease-free survival was 64%. Median time to locoregional recurrence was 36 months. Only esophageal invasion was associated with worse oncologic outcomes. Conclusions: Combined transcervical and transthoracic surgery for advanced thyroid cancer can be performed without mortality and with acceptable morbidity.