Genomic Interactions Between Mycobacterium tuberculosis and Humans
Issued Date
2024-08-01
Resource Type
eISSN
1545293X
Scopus ID
2-s2.0-85202790051
Pubmed ID
38640230
Journal Title
Annual review of genomics and human genetics
Volume
25
Issue
1
Start Page
183
End Page
209
Rights Holder(s)
SCOPUS
Bibliographic Citation
Annual review of genomics and human genetics Vol.25 No.1 (2024) , 183-209
Suggested Citation
Palittapongarnpim P., Tantivitayakul P., Aiewsakun P., Mahasirimongkol S., Jaemsai B. Genomic Interactions Between Mycobacterium tuberculosis and Humans. Annual review of genomics and human genetics Vol.25 No.1 (2024) , 183-209. 209. doi:10.1146/annurev-genom-021623-101844 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/101119
Title
Genomic Interactions Between Mycobacterium tuberculosis and Humans
Author's Affiliation
Corresponding Author(s)
Other Contributor(s)
Abstract
Mycobacterium tuberculosis is considered by many to be the deadliest microbe, with the estimated annual cases numbering more than 10 million. The bacteria, including Mycobacterium africanum, are classified into nine major lineages and hundreds of sublineages, each with different geographical distributions and levels of virulence. The phylogeographic patterns can be a result of recent and early human migrations as well as coevolution between the bacteria and various human populations, which may explain why many studies on human genetic factors contributing to tuberculosis have not been replicable in different areas. Moreover, several studies have revealed the significance of interactions between human genetic variations and bacterial genotypes in determining the development of tuberculosis, suggesting coadaptation. The increased availability of whole-genome sequence data from both humans and bacteria has enabled a better understanding of these interactions, which can inform the development of vaccines and other control measures.