Continuous production of 5-hydroxymethylfurfural: A catalyst-free approach using non-toxic solvents for pharmaceutical applications
Issued Date
2024-05-15
Resource Type
eISSN
26668211
Scopus ID
2-s2.0-85185461900
Journal Title
Chemical Engineering Journal Advances
Volume
18
Rights Holder(s)
SCOPUS
Bibliographic Citation
Chemical Engineering Journal Advances Vol.18 (2024)
Suggested Citation
Tongtummachat T., Jaree A., Thongkan K., Chuphueak W., Akkarawatkhoosith N. Continuous production of 5-hydroxymethylfurfural: A catalyst-free approach using non-toxic solvents for pharmaceutical applications. Chemical Engineering Journal Advances Vol.18 (2024). doi:10.1016/j.ceja.2024.100597 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/97375
Title
Continuous production of 5-hydroxymethylfurfural: A catalyst-free approach using non-toxic solvents for pharmaceutical applications
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Abstract
This work aimed to develop the continuous 5-HMF production process from cane syrup for pharmaceutical applications. A catalyst-free process and a non-toxic solvent were implemented to achieve a cost-effective production process with considerations of safety and environmental impacts. This work studied the roles and influences of various non-toxic organic solvents on production performance and cost. The most common effective solvent (methyl isobutyl ketone) was used as a benchmark. The effects of various operating conditions on the 5-HMF yield and 5-HMF productivity were investigated and optimized based on an experimental design using the most suitable solvent selected. The 5-HMF yield of 66.8 % and 5-HMF production rate of 9.35 × 10−6 kg/h were achieved under the reaction temperature of 190 °C, residence time of 80 min, syrup feed concentration of 25 g/L, and organic-to-aqueous volumetric ratio of 1:1. The satisfactory 5-HMF yield and reasonable 5-HMF production were observed when compared to other processes obtained from the literature. The feasibilities for improving this process was also discussed.