RHINACANTHIN-C: A TARGETED REVIEW ON ITS PHARMACOLOGICAL PROPERTIES AND PROSPECTS FOR DRUG DEVELOPMENT
Issued Date
2024-01-01
Resource Type
ISSN
0858849X
eISSN
25870009
Scopus ID
2-s2.0-86000771427
Journal Title
Suranaree Journal of Science and Technology
Volume
31
Issue
5
Start Page
1
End Page
11
Rights Holder(s)
SCOPUS
Bibliographic Citation
Suranaree Journal of Science and Technology Vol.31 No.5 (2024) , 1-11
Suggested Citation
Suksawat T., Panichayupakaranant P. RHINACANTHIN-C: A TARGETED REVIEW ON ITS PHARMACOLOGICAL PROPERTIES AND PROSPECTS FOR DRUG DEVELOPMENT. Suranaree Journal of Science and Technology Vol.31 No.5 (2024) , 1-11. 11. doi:10.55766/SUJST-2024-05-E05524 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/106808
Title
RHINACANTHIN-C: A TARGETED REVIEW ON ITS PHARMACOLOGICAL PROPERTIES AND PROSPECTS FOR DRUG DEVELOPMENT
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Abstract
Rhinacanthin-C, a naphthoquinone ester derived from Rhinacanthus nasutus (L.) Kurz, has garnered attention due to its broad spectrum of pharmacological properties, particularly in areas such as anticancer, anti-inflammatory, antidiabetic, and neuroprotective activities. As the major bioactive compound of R. nasutus, rhinacanthin-C shows potential as a therapeutic agent for chronic diseases including diabetes, cancer, and neurodegenerative disorders. Recent studies have further explored its pharmacokinetics, safety, and toxicity profiles, highlighting its efficacy and possible clinical applications. Despite its potency, one challenge in the development of rhinacanthin-C for therapeutic use is the cost and complexity of its extraction and purification processes. A promising alternative is the use of rhinacanthins-rich extract (RRE), which offer comparable pharmacological benefits with a low-cost of production. This review illustrates the current findings on rhinacanthin-C, discussing its therapeutic potential, methods for standardization, and prospects for pharmaceutical applications.