Fabrication and in vitro characterization of zinc oxide nanoparticles and hyaluronic acid-containing carboxymethylcellulose gel for wound healing application
Issued Date
2023-01-01
Resource Type
ISSN
10837450
eISSN
10979867
Scopus ID
2-s2.0-85147279124
Pubmed ID
36646681
Journal Title
Pharmaceutical Development and Technology
Volume
28
Issue
1
Start Page
95
End Page
108
Rights Holder(s)
SCOPUS
Bibliographic Citation
Pharmaceutical Development and Technology Vol.28 No.1 (2023) , 95-108
Suggested Citation
Paramadini A.W., Chinavinijkul P., Meemai A., Thongkam P., Apasuthirat A., Nasongkla N. Fabrication and in vitro characterization of zinc oxide nanoparticles and hyaluronic acid-containing carboxymethylcellulose gel for wound healing application. Pharmaceutical Development and Technology Vol.28 No.1 (2023) , 95-108. 108. doi:10.1080/10837450.2022.2164304 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82231
Title
Fabrication and in vitro characterization of zinc oxide nanoparticles and hyaluronic acid-containing carboxymethylcellulose gel for wound healing application
Author's Affiliation
Other Contributor(s)
Abstract
Chronic wounds, such as burns and diabetic ulcers, are complex wounds sustained by the skin that require life-long rehabilitation and have the potential to deteriorate and get infected. The number of patients with this ailment has been steadily increasing. This illness demands the use of new dressings with the best capabilities for managing wound healing. This study created an gel with carboxymethylcellulose (CMC), hyaluronic acid (HA), and zinc oxide nanoparticles (ZnO NPs). According to the findings, the manufacturing technique with a 1:4 ratio of HA and CMC gel had the best viscosity. Additionally, varying concentrations of zinc oxide nanoparticles (ZnO NPs) were added to the formula. Variations included 0.05, 0.125, 0.5, 1.0, 3.0, 5.0, and 10% by weight. In order to find the ideal dose and formulation, physical properties, an anti-bacterial test, and a cell migration assay were carried out. The samples with concentration of 0.5, 1.0, 3.0, 5.0 and 10% w/v showed ability to kill gram-positive and gram-negative bacteria. Wound healing experiments showed that cells proliferated for HA/CMC/ZnO gel with a weight-to-volume ratio of 0.05% and 1.0% w/v. In conclusion, according to all (physical and biological) characterization, the HA/CMC/ZnO gel with a weight-to-volume ratio of 1.0% w/v was found to have a considerable standard for wound-healing materials, demonstrating a promising effect against bacteria.