In vitro antidiabetic and antihypercholesterolemic activities of camel milk protein hydrolysates derived upon simulated gastrointestinal digestion of milk from different camel breeds
Issued Date
2023-05-01
Resource Type
ISSN
00220302
eISSN
15253198
Scopus ID
2-s2.0-85150240489
Pubmed ID
36935238
Journal Title
Journal of Dairy Science
Volume
106
Issue
5
Start Page
3098
End Page
3108
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Dairy Science Vol.106 No.5 (2023) , 3098-3108
Suggested Citation
Mudgil P., Redha A.A., Nirmal N.P., Maqsood S. In vitro antidiabetic and antihypercholesterolemic activities of camel milk protein hydrolysates derived upon simulated gastrointestinal digestion of milk from different camel breeds. Journal of Dairy Science Vol.106 No.5 (2023) , 3098-3108. 3108. doi:10.3168/jds.2022-22701 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/81596
Title
In vitro antidiabetic and antihypercholesterolemic activities of camel milk protein hydrolysates derived upon simulated gastrointestinal digestion of milk from different camel breeds
Author(s)
Other Contributor(s)
Abstract
Milk protein hydrolysates derived from 4 camel breeds (Pakistani, Saheli, Hozami, and Omani) were evaluated for in vitro inhibition of antidiabetic enzymatic markers (dipeptidyl peptidase IV and α-amylase) and antihypercholesterolemic enzymatic markers (pancreatic lipase and cholesterol esterase). Milk samples were subjected to in vitro simulated gastric (SGD) and gastrointestinal digestion (SGID) conditions. In comparison with intact milk proteins, the SGD-derived milk protein hydrolysates showed enhanced inhibition of α-amylase, dipeptidyl peptidase IV, pancreatic lipase, and cholesterol esterase as reflected by lower half-maximal inhibitory concentration values. Overall, milk protein hydrolysates derived from the milk of Hozami and Omani camel breeds displayed higher inhibition of different enzymatic markers compared with milk protein hydrolysates from Pakistani and Saheli breeds. In vitro SGD and SGID processes significantly increased the bioactive properties of milk from all camel breeds. Milk protein hydrolysates from different camel breeds showed significant variations for inhibition of antidiabetic and antihypercholesterolemic enzymatic markers, suggesting the importance of breed selection for production of bioactive peptides. However, further studies on identifying the peptides generated upon SGD and SGID of milk from different camel breeds are needed.