Regenerative treatments for scleroderma in cutaneous manifestations of the face: a systematic review
Issued Date
2024-08-01
Resource Type
ISSN
0392856X
Scopus ID
2-s2.0-85201727108
Pubmed ID
38976297
Journal Title
Clinical and experimental rheumatology
Volume
42
Issue
8
Start Page
1675
End Page
1689
Rights Holder(s)
SCOPUS
Bibliographic Citation
Clinical and experimental rheumatology Vol.42 No.8 (2024) , 1675-1689
Suggested Citation
Schipper J.A.M., Verhoef L.L., Schepers R.H., Dijkstra P.U., Stel A.J., van der Werf S., Mulder D.J., Harmsen M.C., Jansma J. Regenerative treatments for scleroderma in cutaneous manifestations of the face: a systematic review. Clinical and experimental rheumatology Vol.42 No.8 (2024) , 1675-1689. 1689. doi:10.55563/clinexprheumatol/y2p4ib Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/100636
Title
Regenerative treatments for scleroderma in cutaneous manifestations of the face: a systematic review
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Corresponding Author(s)
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Abstract
OBJECTIVES: Scleroderma is a heterogeneous chronic autoimmune disease affecting connective tissue, characterised by chronic inflammation and fibrosis, particularly affecting internal organs and skin. Orofacial involvement is common, leading to facial atrophy, mask-like appearance and difficulties in function that significantly impact patients' quality of life. This systematic review evaluates different autologous regenerative treatments of facial manifestations of scleroderma, aiming to provide comprehensive understanding of their effectiveness in reducing fibrosis, and thereby improving function and skin quality. METHODS: A search in PubMed, Embase, Web of Science Core Collection, Cochrane CENTRAL, and CINAHL was conducted. Studies assessing autologous regenerative treatments in cutaneous manifestations of the face in scleroderma patients were included. Outcomes of interest were treatment characteristics, characterisation of biomaterials, outcome measurements and patient satisfaction. Methodological quality was assessed with the Effective Public Health Practice Project tool. RESULTS: In total 18 studies were included. Methodological quality of studies was weak (n=15) and moderate (n=3). Treatments consisted of autologous fat grafting, platelet-rich plasma, stromal vascular fraction, and adipose-derived stem cells. In general, most studies showed improvements of symptoms, but no treatment was considered superior. CONCLUSIONS: Autologous regenerative treatments hold potential for alleviating cutaneous manifestations of the face in scleroderma. Further clinical trials should be well-designed to improve the quality of clinical evidence.