Cardiovascular Complications of Down Syndrome: Scoping Review and Expert Consensus
Issued Date
2023-01-31
Resource Type
ISSN
00097322
eISSN
15244539
Scopus ID
2-s2.0-85147150771
Pubmed ID
36716257
Journal Title
Circulation
Volume
147
Issue
5
Start Page
425
End Page
441
Rights Holder(s)
SCOPUS
Bibliographic Citation
Circulation Vol.147 No.5 (2023) , 425-441
Suggested Citation
Dimopoulos K., Constantine A., Clift P., Condliffe R., Moledina S., Jansen K., Inuzuka R., Veldtman G.R., Cua C.L., Tay E.L.W., Opotowsky A.R., Giannakoulas G., Alonso-Gonzalez R., Cordina R., Capone G., Namuyonga J., Scott C.H., D'Alto M., Gamero F.J., Chicoine B., Gu H., Limsuwan A., Majekodunmi T., Budts W., Coghlan G., Broberg C.S. Cardiovascular Complications of Down Syndrome: Scoping Review and Expert Consensus. Circulation Vol.147 No.5 (2023) , 425-441. 441. doi:10.1161/CIRCULATIONAHA.122.059706 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82447
Title
Cardiovascular Complications of Down Syndrome: Scoping Review and Expert Consensus
Author(s)
Dimopoulos K.
Constantine A.
Clift P.
Condliffe R.
Moledina S.
Jansen K.
Inuzuka R.
Veldtman G.R.
Cua C.L.
Tay E.L.W.
Opotowsky A.R.
Giannakoulas G.
Alonso-Gonzalez R.
Cordina R.
Capone G.
Namuyonga J.
Scott C.H.
D'Alto M.
Gamero F.J.
Chicoine B.
Gu H.
Limsuwan A.
Majekodunmi T.
Budts W.
Coghlan G.
Broberg C.S.
Constantine A.
Clift P.
Condliffe R.
Moledina S.
Jansen K.
Inuzuka R.
Veldtman G.R.
Cua C.L.
Tay E.L.W.
Opotowsky A.R.
Giannakoulas G.
Alonso-Gonzalez R.
Cordina R.
Capone G.
Namuyonga J.
Scott C.H.
D'Alto M.
Gamero F.J.
Chicoine B.
Gu H.
Limsuwan A.
Majekodunmi T.
Budts W.
Coghlan G.
Broberg C.S.
Author's Affiliation
Advocate Medical Group
Ramathibodi Hospital
Makerere University College of Health Sciences
Golden Jubilee National Hospital
Nationwide Children’s Hospital
Beijing Anzhen Hospital, Capital Medical University
University Hospital of the West Indies
The Royal Free Hospital
OHSU School of Medicine
National University Hospital
KU Leuven– University Hospital Leuven
Kennedy Krieger Institute
University General Hospital of Thessaloniki "AHEPA"
Università degli Studi della Campania Luigi Vanvitelli
The University of Sydney
University College London
Great Ormond Street Hospital for Children NHS Foundation Trust
University of Cincinnati College of Medicine
University of Toronto
Queen Elizabeth Hospital Birmingham
National Heart and Lung Institute
Royal Brompton Hospital
Royal Hallamshire Hospital
Newcastle University
The University of Tokyo Hospital
The Newcastle Upon Tyne Hospitals NHS Foundation Trust
Johns Hopkins School of Medicine
Euracare Multi-Specialist Hospital
Toronto Adult Congenital Heart Disease Program
Benjamin Bloom Children's Hospital
Uganda Heart Institute
Ramathibodi Hospital
Makerere University College of Health Sciences
Golden Jubilee National Hospital
Nationwide Children’s Hospital
Beijing Anzhen Hospital, Capital Medical University
University Hospital of the West Indies
The Royal Free Hospital
OHSU School of Medicine
National University Hospital
KU Leuven– University Hospital Leuven
Kennedy Krieger Institute
University General Hospital of Thessaloniki "AHEPA"
Università degli Studi della Campania Luigi Vanvitelli
The University of Sydney
University College London
Great Ormond Street Hospital for Children NHS Foundation Trust
University of Cincinnati College of Medicine
University of Toronto
Queen Elizabeth Hospital Birmingham
National Heart and Lung Institute
Royal Brompton Hospital
Royal Hallamshire Hospital
Newcastle University
The University of Tokyo Hospital
The Newcastle Upon Tyne Hospitals NHS Foundation Trust
Johns Hopkins School of Medicine
Euracare Multi-Specialist Hospital
Toronto Adult Congenital Heart Disease Program
Benjamin Bloom Children's Hospital
Uganda Heart Institute
Other Contributor(s)
Abstract
Cardiovascular disease is a leading cause of morbidity and mortality in individuals with Down syndrome. Congenital heart disease is the most common cardiovascular condition in this group, present in up to 50% of people with Down syndrome and contributing to poor outcomes. Additional factors contributing to cardiovascular outcomes include pulmonary hypertension; coexistent pulmonary, endocrine, and metabolic diseases; and risk factors for atherosclerotic disease. Moreover, disparities in the cardiovascular care of people with Down syndrome compared with the general population, which vary across different geographies and health care systems, further contribute to cardiovascular mortality; this issue is often overlooked by the wider medical community. This review focuses on the diagnosis, prevalence, and management of cardiovascular disease encountered in people with Down syndrome and summarizes available evidence in 10 key areas relating to Down syndrome and cardiac disease, from prenatal diagnosis to disparities in care in areas of differing resource availability. All specialists and nonspecialist clinicians providing care for people with Down syndrome should be aware of best clinical practice in all aspects of care of this distinct population.