Patients With Chronic Spontaneous Urticaria Who Have Wheals, Angioedema, or Both, Differ Demographically, Clinically, and in Response to Treatment—Results From CURE
Issued Date
2023-01-01
Resource Type
ISSN
22132198
Scopus ID
2-s2.0-85169512340
Pubmed ID
37604426
Journal Title
Journal of Allergy and Clinical Immunology: In Practice
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Allergy and Clinical Immunology: In Practice (2023)
Suggested Citation
Buttgereit T., Vera C., Aulenbacher F., Church M.K., Hawro T., Asero R., Bauer A., Bizjak M., Bouillet L., Dissemond J., Fomina D., Giménez-Arnau A.M., Grattan C., Gregoriou S., Kulthanan K., Kasperska-Zajac A., Kocatürk E., Makris M., Kolkhir P., Weller K., Magerl M., Maurer M. Patients With Chronic Spontaneous Urticaria Who Have Wheals, Angioedema, or Both, Differ Demographically, Clinically, and in Response to Treatment—Results From CURE. Journal of Allergy and Clinical Immunology: In Practice (2023). doi:10.1016/j.jaip.2023.08.020 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/89619
Title
Patients With Chronic Spontaneous Urticaria Who Have Wheals, Angioedema, or Both, Differ Demographically, Clinically, and in Response to Treatment—Results From CURE
Author's Affiliation
Universitätsklinikum Carl Gustav Carus Dresden
Siriraj Hospital
Bolnišnica Golnik
Universitat Pompeu Fabra Barcelona
National and Kapodistrian University of Athens
Slaski Uniwersytet Medyczny w Katowicach
Charité – Universitätsmedizin Berlin
Universitätsklinikum Schleswig-Holstein Campus Lübeck
Universität Duisburg-Essen
Sechenov First Moscow State Medical University
Guy's Hospital
Koç Üniversitesi
Centre Hospitalier Universitaire de Grenoble
Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP)
Clinical State Hospital 52
Clinica San Carlo
Siriraj Hospital
Bolnišnica Golnik
Universitat Pompeu Fabra Barcelona
National and Kapodistrian University of Athens
Slaski Uniwersytet Medyczny w Katowicach
Charité – Universitätsmedizin Berlin
Universitätsklinikum Schleswig-Holstein Campus Lübeck
Universität Duisburg-Essen
Sechenov First Moscow State Medical University
Guy's Hospital
Koç Üniversitesi
Centre Hospitalier Universitaire de Grenoble
Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP)
Clinical State Hospital 52
Clinica San Carlo
Other Contributor(s)
Abstract
Background: Patients with chronic spontaneous urticaria (CSU) have spontaneous wheals (W), angioedema (AE), or both, for longer than 6 weeks. Clinical differences between patients with standalone W, standalone AE, and W and AE (W+AE) remain incompletely understood. Objective: To compare W, AE, and W+AE CSU patients regarding demographics, disease characteristics, comorbidities, disease burden, and treatment response. Methods: Baseline data from 3,698 CSU patients in the ongoing, prospective, international, multicenter, observational Chronic Urticaria REgistry (CURE) were analyzed (data cut: September 2022). Results: Across all CSU patients, 59%, 36%, and 5% had W+AE, W, and AE, respectively. The W+AE patients, compared with W and AE patients, showed the lowest male-to-female ratio (0.33), higher rates of concomitant psychiatric disease (17% vs 11% vs 6%, respectively), autoimmune disease (13% vs 7% vs 9%, respectively), and nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity (9% vs 5% vs 2%, respectively) and the highest disease impact. The W patients, compared with W+AE and AE patients, showed the lowest rates of concomitant hypertension (15% vs 21% vs 40%, respectively) and obesity (11% vs 16% vs 17%, respectively), the highest rate of concomitant inducible urticaria (24% vs 22% vs 6%, respectively), and shorter W duration. The AE patients, compared with W+AE and W patients, were older at disease onset, showed longer AE duration, and the best response to increased doses of H1-antihistamines (58% vs 24% vs 31%, respectively) and omalizumab (92% vs 67% vs 60%, respectively). Conclusions: Our findings provide a better understanding of CSU phenotypes and may guide patient care and research efforts that aim to link them to pathogenic drivers.