Surveillance of avian influenza through bird guano in remote regions of the global south to uncover transmission dynamics
1
Issued Date
2025-12-01
Resource Type
eISSN
20411723
Scopus ID
2-s2.0-105007052935
Pubmed ID
40425586
Journal Title
Nature Communications
Volume
16
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Nature Communications Vol.16 No.1 (2025)
Suggested Citation
Wannigama D.L., Amarasiri M., Phattharapornjaroen P., Hurst C., Modchang C., Besa J.J.V., Miyanaga K., Cui L., Fernandez S., Huang A.T., Ounjai P., Werawatte W.K.C.P., Ali A.H., Vatanaprasan P., Jay D.J., Saethang T., Luk-in S., Kanthawee P., Thuptimdang W., Tacharoenmuang R., Cynthia B., Vitharana S.P.H.S., Ngamwongsatit N., Ishikawa H., Furukawa T., Wang Y., Singer A.C., Ragupathi N.K.D., Chatsuwan T., Sei K., Nanbo A., Leelahavanichkul A., Kanjanabuch T., Hamamoto H., Higgins P.G., Sano D., Kicic A., Valdebenito J.O., Bonnedahl J., Trowsdale S., Hongsing P., Khatib A., Shibuya K., Abe S. Surveillance of avian influenza through bird guano in remote regions of the global south to uncover transmission dynamics. Nature Communications Vol.16 No.1 (2025). doi:10.1038/s41467-025-59322-z Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/110579
Title
Surveillance of avian influenza through bird guano in remote regions of the global south to uncover transmission dynamics
Author(s)
Wannigama D.L.
Amarasiri M.
Phattharapornjaroen P.
Hurst C.
Modchang C.
Besa J.J.V.
Miyanaga K.
Cui L.
Fernandez S.
Huang A.T.
Ounjai P.
Werawatte W.K.C.P.
Ali A.H.
Vatanaprasan P.
Jay D.J.
Saethang T.
Luk-in S.
Kanthawee P.
Thuptimdang W.
Tacharoenmuang R.
Cynthia B.
Vitharana S.P.H.S.
Ngamwongsatit N.
Ishikawa H.
Furukawa T.
Wang Y.
Singer A.C.
Ragupathi N.K.D.
Chatsuwan T.
Sei K.
Nanbo A.
Leelahavanichkul A.
Kanjanabuch T.
Hamamoto H.
Higgins P.G.
Sano D.
Kicic A.
Valdebenito J.O.
Bonnedahl J.
Trowsdale S.
Hongsing P.
Khatib A.
Shibuya K.
Abe S.
Amarasiri M.
Phattharapornjaroen P.
Hurst C.
Modchang C.
Besa J.J.V.
Miyanaga K.
Cui L.
Fernandez S.
Huang A.T.
Ounjai P.
Werawatte W.K.C.P.
Ali A.H.
Vatanaprasan P.
Jay D.J.
Saethang T.
Luk-in S.
Kanthawee P.
Thuptimdang W.
Tacharoenmuang R.
Cynthia B.
Vitharana S.P.H.S.
Ngamwongsatit N.
Ishikawa H.
Furukawa T.
Wang Y.
Singer A.C.
Ragupathi N.K.D.
Chatsuwan T.
Sei K.
Nanbo A.
Leelahavanichkul A.
Kanjanabuch T.
Hamamoto H.
Higgins P.G.
Sano D.
Kicic A.
Valdebenito J.O.
Bonnedahl J.
Trowsdale S.
Hongsing P.
Khatib A.
Shibuya K.
Abe S.
Author's Affiliation
Women and Marginalized Health Research Alliance
The Lygodium Ceylon Health and Environmental Policy Research Center
Kite Pharma Inc.
National Institute of Health
Catholic University of Madagascar
Bioberrys Healthcare and Research Centre
Partner Site Bonn-Cologne
University of Cambridge
St. Carolus Hospital
The Tokyo Foundation for Policy Research
Perth Children's Hospital
Faculty of Medicine, Prince of Songkla University
Universidad de Las Américas Chile
King Chulalongkorn Memorial Hospital
Kasetsart University
Instituto Milenio Biodiversidad de Ecosistemas Antárticos y Subantárticos
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Linköpings Universitet
UK Centre for Ecology & Hydrology
The University of Auckland
Mahidol University
Ministry of Higher Education, Science, Research and Innovation
Faculty of Medicine, Chulalongkorn University
Kitasato University
Armed Forces Research Institute of Medical Sciences, Thailand
Medizinische Fakultät
UWA Medical School
Yamagata University Faculty of Medicine
MHESI
Faculty of Medicine, Thammasat University
The University of Queensland
Jichi Medical University
University of the Philippines College of Medicine
Thammasat University
Chulalongkorn University
Nagasaki University
Yamagata Prefectural Central Hospital
Wayamba University of Sri Lanka
Faculty of Science, Mahidol University
Mae Fah Luang University
University of Toronto Faculty of Medicine
Yamagata Prefectural University of Health Sciences
Hospital of Chongqing University
Universidad de Concepcion
Chulabhorn Royal Academy
Curtin University
The University of Sheffield
The Kids Research Institute Australia
Tohoku University
The Lygodium Ceylon Health and Environmental Policy Research Center
Kite Pharma Inc.
National Institute of Health
Catholic University of Madagascar
Bioberrys Healthcare and Research Centre
Partner Site Bonn-Cologne
University of Cambridge
St. Carolus Hospital
The Tokyo Foundation for Policy Research
Perth Children's Hospital
Faculty of Medicine, Prince of Songkla University
Universidad de Las Américas Chile
King Chulalongkorn Memorial Hospital
Kasetsart University
Instituto Milenio Biodiversidad de Ecosistemas Antárticos y Subantárticos
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Linköpings Universitet
UK Centre for Ecology & Hydrology
The University of Auckland
Mahidol University
Ministry of Higher Education, Science, Research and Innovation
Faculty of Medicine, Chulalongkorn University
Kitasato University
Armed Forces Research Institute of Medical Sciences, Thailand
Medizinische Fakultät
UWA Medical School
Yamagata University Faculty of Medicine
MHESI
Faculty of Medicine, Thammasat University
The University of Queensland
Jichi Medical University
University of the Philippines College of Medicine
Thammasat University
Chulalongkorn University
Nagasaki University
Yamagata Prefectural Central Hospital
Wayamba University of Sri Lanka
Faculty of Science, Mahidol University
Mae Fah Luang University
University of Toronto Faculty of Medicine
Yamagata Prefectural University of Health Sciences
Hospital of Chongqing University
Universidad de Concepcion
Chulabhorn Royal Academy
Curtin University
The University of Sheffield
The Kids Research Institute Australia
Tohoku University
Corresponding Author(s)
Other Contributor(s)
Abstract
Avian influenza viruses (AIVs) pose a growing global health threat, particularly in low- and middle-income countries (LMICs), where limited surveillance capacity and under-resourced healthcare systems hinder timely detection and response. Migratory birds play a significant role in the transboundary spread of AIVs, yet data from key regions along migratory flyways remain sparse. To address these surveillance gaps, we conducted a study between December 2021 and February 2023 using fresh bird guano collected across 10 countries in the Global South. Here, we show that remote, uninhabited regions in previously unsampled areas harbor a high diversity of AIV strains, with H5N1 emerging as the most prevalent. Some of these H5N1 samples also carry mutations that may make them less responsive to the antiviral drug oseltamivir. Our findings documented the presence of AIVs in several underrepresented regions and highlighted critical transmission hotspots where viral evolution may be accelerating. These results underscore the urgent need for geographically targeted surveillance to detect emerging variants, inform public health interventions, and reduce the risk of zoonotic spillover.