Plasmodium vivax malaria serological exposure markers: Assessing the degree and implications of cross-reactivity with P. knowlesi
Issued Date
2022-06-21
Resource Type
eISSN
26663791
Scopus ID
2-s2.0-85132610519
Pubmed ID
35732155
Journal Title
Cell Reports Medicine
Volume
3
Issue
6
Rights Holder(s)
SCOPUS
Bibliographic Citation
Cell Reports Medicine Vol.3 No.6 (2022)
Suggested Citation
Longley R.J., Grigg M.J., Schoffer K., Obadia T., Hyslop S., Piera K.A., Nekkab N., Mazhari R., Takashima E., Tsuboi T., Harbers M., Tetteh K., Drakeley C., Chitnis C.E., Healer J., Tham W.H., Sattabongkot J., White M.T., Cooper D.J., Rajahram G.S., Barber B.E., William T., Anstey N.M., Mueller I. Plasmodium vivax malaria serological exposure markers: Assessing the degree and implications of cross-reactivity with P. knowlesi. Cell Reports Medicine Vol.3 No.6 (2022). doi:10.1016/j.xcrm.2022.100662 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/83694
Title
Plasmodium vivax malaria serological exposure markers: Assessing the degree and implications of cross-reactivity with P. knowlesi
Author's Affiliation
RIKEN Center for Integrative Medical Sciences
Faculty of Tropical Medicine, Mahidol University
Université Paris Cité
Department of Medicine
London School of Hygiene & Tropical Medicine
Walter and Eliza Hall Institute of Medical Research
University of Melbourne
Menzies School of Health Research
Ehime University
Institut Pasteur, Paris
Ltd.
Gleneagles Hospital
INFECTIOUS DISEASE SOCIETY KOTA KINABALU
Hospital Queen Elizabeth II
Faculty of Tropical Medicine, Mahidol University
Université Paris Cité
Department of Medicine
London School of Hygiene & Tropical Medicine
Walter and Eliza Hall Institute of Medical Research
University of Melbourne
Menzies School of Health Research
Ehime University
Institut Pasteur, Paris
Ltd.
Gleneagles Hospital
INFECTIOUS DISEASE SOCIETY KOTA KINABALU
Hospital Queen Elizabeth II
Other Contributor(s)
Abstract
Serological markers are a promising tool for surveillance and targeted interventions for Plasmodium vivax malaria. P. vivax is closely related to the zoonotic parasite P. knowlesi, which also infects humans. P. vivax and P. knowlesi are co-endemic across much of South East Asia, making it important to design serological markers that minimize cross-reactivity in this region. To determine the degree of IgG cross-reactivity against a panel of P. vivax serological markers, we assayed samples from human patients with P. knowlesi malaria. IgG antibody reactivity is high against P. vivax proteins with high sequence identity with their P. knowlesi ortholog. IgG reactivity peaks at 7 days post-P. knowlesi infection and is short-lived, with minimal responses 1 year post-infection. We designed a panel of eight P. vivax proteins with low levels of cross-reactivity with P. knowlesi. This panel can accurately classify recent P. vivax infections while reducing misclassification of recent P. knowlesi infections.