Safety Evaluation for Acute and Chronic Oral Toxicity of Maha Pigut Triphala Contains Three Medicinal Fruits in Sprague-Dawley Rats
Issued Date
2024-12-01
Resource Type
eISSN
20797737
Scopus ID
2-s2.0-85213227146
Journal Title
Biology
Volume
13
Issue
12
Rights Holder(s)
SCOPUS
Bibliographic Citation
Biology Vol.13 No.12 (2024)
Suggested Citation
Intatham S., Taychaworaditsakul W., Khonsung P., Chansakaow S., Jaijoy K., Lertprasertsuke N., Soonthornchareonnon N., Sireeratawong S. Safety Evaluation for Acute and Chronic Oral Toxicity of Maha Pigut Triphala Contains Three Medicinal Fruits in Sprague-Dawley Rats. Biology Vol.13 No.12 (2024). doi:10.3390/biology13121005 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/102598
Title
Safety Evaluation for Acute and Chronic Oral Toxicity of Maha Pigut Triphala Contains Three Medicinal Fruits in Sprague-Dawley Rats
Corresponding Author(s)
Other Contributor(s)
Abstract
Maha Pigut Triphala is a herbal formula composed of dry fruits of three plants, namely, Terminalia bellirica, Terminalia chebula, and Emblica officinalis also known as Phyllanthus emblica, which are used in different proportions in traditional Thai medicine. This formula has long been used to treat colds, relieve coughing, and alleviate phlegm. Nevertheless, there have been no studies on the safety of Maha Pigut Triphala in the ratio of 2:1:3. Thereby, this study aimed to investigate the acute and chronic oral toxicity of Maha Pigut Triphala in the ratio of 2:1:3 in Sprague-Dawley rats. The results showed that the rats that were given a single dose of Maha Pigut Triphala and those that received Maha Pigut Triphala once daily for 270 days in acute and chronic oral toxicity studies, respectively, did not exhibit any abnormal behaviors or mortality. There were only minor changes in body weight, organ weight, hematological and blood chemistry values. However, gross pathological and histopathological studies revealed no abnormalities in the internal organs. Therefore, it can be concluded that Maha Pigut Triphala in the ratio of 2:1:3 causes neither acute nor chronic oral toxicity in rats. Additionally, the present study provides safety information on Maha Pigut Triphala in animals that could help guide future studies in humans.