Simplified fabrication of laminated paper-based analytical device (LPAD) with color-palette mobile app for analysis of salicylic acid in pharmaceutical products
Issued Date
2022-03-01
Resource Type
ISSN
09106340
eISSN
13482246
Scopus ID
2-s2.0-85127408629
Pubmed ID
35359271
Journal Title
Analytical Sciences
Volume
38
Issue
3
Start Page
533
End Page
540
Rights Holder(s)
SCOPUS
Bibliographic Citation
Analytical Sciences Vol.38 No.3 (2022) , 533-540
Suggested Citation
Noirahaeng N., Uraisin K., Wattanasin P., Saetear P. Simplified fabrication of laminated paper-based analytical device (LPAD) with color-palette mobile app for analysis of salicylic acid in pharmaceutical products. Analytical Sciences Vol.38 No.3 (2022) , 533-540. 540. doi:10.2116/analsci.21P231 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/84202
Title
Simplified fabrication of laminated paper-based analytical device (LPAD) with color-palette mobile app for analysis of salicylic acid in pharmaceutical products
Author(s)
Other Contributor(s)
Abstract
In this work, we present for the first time, a simplified fabrication of a laminated paper-based analytical device (LPAD) with a free-mobile app, Palette Cam, for image analysis. A filter paper is cut in a rectangular shape (9 × 3 cm) and placed between a top laminating sheet with punched holes and a bottom laminating sheet. The holes allow accessibility of liquid on the paper. Thermal lamination is then employed to complete the fabrication of LPAD. Our simplified design reduces a tedious alignment of small pieces of paper to the holes. We demonstrated the LPAD with an analysis of salicylic acid in pharmaceutical products. Each 4 μL of ferric reagent and sample was dispensed on the LPAD. Smartphone was used to capture images. The RGB (red green blue) color intensity from the Palette Cam was converted into a logarithm color ratio. Our LPAD is simplified, cost-effective and able to be a portable device. Graphical abstract: [Figure not available: see fulltext.]