Epithelial and fibroblast SPARC expression patterns in oral leukoplakia and oral squamous cell carcinoma
Issued Date
2022-08-01
Resource Type
ISSN
22124403
Scopus ID
2-s2.0-85124510254
Pubmed ID
35165061
Journal Title
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume
134
Issue
2
Start Page
e44
End Page
e50
Rights Holder(s)
SCOPUS
Bibliographic Citation
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Vol.134 No.2 (2022) , e44-e50
Suggested Citation
Poomsawat S., Kosanwat T., Meesakul O., Sanguansin S. Epithelial and fibroblast SPARC expression patterns in oral leukoplakia and oral squamous cell carcinoma. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Vol.134 No.2 (2022) , e44-e50. e50. doi:10.1016/j.oooo.2021.10.019 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85700
Title
Epithelial and fibroblast SPARC expression patterns in oral leukoplakia and oral squamous cell carcinoma
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Objective: This study evaluated and compared the expression of secreted protein acidic and rich in cysteine (SPARC) in epithelial cells and fibroblasts of oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC) using normal oral mucosa as a control. Study Design: The expression of SPARC was determined in samples of normal oral mucosa (n = 12), OL without dysplasia (n = 31), OL with dysplasia (n = 54), and OSCC (n = 69) using immunohistochemistry. The percentage of positive cells in epithelial cells and fibroblasts was independently evaluated. Results: Epithelial SPARC was found in 33.3%, 35.5%, 25.9%, and 66.7% of normal oral mucosa, OL without dysplasia, OL with dysplasia, and OSCC, respectively. Fibroblast SPARC was found in 50.0%, 29.0%, 46.3%, and 84.1% of normal oral mucosa, OL without dysplasia, OL with dysplasia, and OSCC, respectively. OSCC had higher epithelial and fibroblast SPARC expression than normal oral mucosa, OL without dysplasia, and OL with dysplasia (P < .05). No significant differences were observed in epithelial and fibroblast SPARC among normal oral mucosa or OL with and without dysplasia. Conclusion: Overexpression of epithelial and fibroblast SPARC was observed in OSCC but not in OL, suggesting that SPARC is involved in the late stage of oral carcinogenesis.