Usefulness of apparent diffusion coefficient values for distinguishing between squamous cell carcinoma and malignant salivary gland tumor of the head and neck
Issued Date
2023-01-01
Resource Type
ISSN
19714009
eISSN
23851996
Scopus ID
2-s2.0-85150619468
Pubmed ID
36898679
Journal Title
Neuroradiology Journal
Rights Holder(s)
SCOPUS
Bibliographic Citation
Neuroradiology Journal (2023)
Suggested Citation
Panyaping T., Tepkidakarn N., Kiatthanabumrung S., Wattanatranon D., Tritanon O. Usefulness of apparent diffusion coefficient values for distinguishing between squamous cell carcinoma and malignant salivary gland tumor of the head and neck. Neuroradiology Journal (2023). doi:10.1177/19714009231163561 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82553
Title
Usefulness of apparent diffusion coefficient values for distinguishing between squamous cell carcinoma and malignant salivary gland tumor of the head and neck
Author's Affiliation
Other Contributor(s)
Abstract
Purpose: The aim of the study was to assess the usefulness of apparent diffusion coefficient (ADC) values for differentiating between SCC and malignant salivary gland tumors of the head and neck. Materials and methods: This retrospective cross-sectional study was conducted on 29 patients with SCCs and 10 patients with malignant salivary gland tumors who underwent pretreatment MRI of the head and neck. The minimum and average ADC values of the tumors were measured, with normalized tumor to spinal cord ADC ratios generated. Comparisons of ADC values and normalized ADC ratios between the two tumor types were performed using the unpaired t-test. Results: The minimum and average ADC values and normalized average ADC ratios of SCCs (753.17 ± 214.47 × 10−6 mm2/s, 848.79 ± 250.13 × 10−6 mm2/s, and 0.92 ± 0.25, respectively) were significantly lower than those of malignant salivary gland tumors (1084.90 ± 242.60 × 10−6 mm2/s, 1305.90 ± 270.99 × 10−6 mm2/s, and 1.58 ± 0.31, respectively; all p < 0.001). A cutoff value of 1.31 for the normalized average ADC ratio was used to distinguish between SCCs and malignant salivary gland tumors and achieved an area under the curve of 0.93, sensitivity of 96.6%, specificity of 90%, and accuracy of 94.6%. Conclusion: ADC value measurement could help differentiate between SCCs and malignant salivary gland tumors.