Intravoxel incoherent motion for differentiating residual/recurrent tumor from post-treatment change in patients with high-grade glioma
Issued Date
2023-01-01
Resource Type
ISSN
19714009
eISSN
23851996
Scopus ID
2-s2.0-85159077917
Pubmed ID
37105183
Journal Title
Neuroradiology Journal
Rights Holder(s)
SCOPUS
Bibliographic Citation
Neuroradiology Journal (2023)
Suggested Citation
Tunlayadechanont P., Panyaping T., Chansakul T., Hirunpat P., Kampaengtip A. Intravoxel incoherent motion for differentiating residual/recurrent tumor from post-treatment change in patients with high-grade glioma. Neuroradiology Journal (2023). doi:10.1177/19714009231173108 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82784
Title
Intravoxel incoherent motion for differentiating residual/recurrent tumor from post-treatment change in patients with high-grade glioma
Author's Affiliation
Other Contributor(s)
Abstract
Purpose: To investigate the diagnostic value of f derived from IVIM technique and to correlate it with rCBV derived from DSC for the differentiation of residual/recurrent tumor from post-treatment change in patients with high-grade glioma. Materials and Methods: Patients who underwent MR imaging with IVIM and DSC studies for evaluation of high-grade glioma after standard treatment were enrolled in this retrospective study. For qualitative analysis, the f and rCBV maps were interpreted as hypoperfused or hyperperfused in each parameter. Quantitative analysis was performed using ROI analysis in f and rCBV parameters. The lesions were divided into residual/recurrent tumor and post-treatment change groups. Results: Nineteen patients with high-grade glioma were included. In qualitative analysis, the f-map shows higher sensitivity (100.0%) than rCBV map (92.3%), while the rCBV map shows higher specificity (100.0%) than the f-map (83.3%). In quantitative analysis, the optimal cutoff values of 1.19 for f and 1.06 for rCBV are shown to provide high diagnostic value with high sensitivity (91.7%) for both parameters but slightly higher specificity of rCBV (85.7%) than f (71.4%). The correlation between f and rCBV was good with ICC of 0.810. Conclusion: The f value measured by IVIM technique, non-contrast perfusion technique, has high diagnostic performance and potential to be an alternative method to CBV measured by DSC for differentiation between residual/recurrent tumor and post-treatment change in patients with high-grade glioma.