Clinical Outcomes of Rotational Atherectomy in Heavily Calcified Lesions: Evidence From the Largest Cardiac Center in Thailand
5
Issued Date
2022-01-01
Resource Type
ISSN
22118160
eISSN
22118179
DOI
Scopus ID
2-s2.0-85141981433
Pubmed ID
36382162
Journal Title
Global Heart
Volume
17
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Global Heart Vol.17 No.1 (2022)
Suggested Citation
Towashiraporn K., Krittayaphong R., Tresukosol D., Phankingthongkum R., Tungsubutra W., Wongpraparut N., Chunhamaneewat N., Phichaphop A., Panchavinnin P., Reanthong T., Chotinaiwattarakul C. Clinical Outcomes of Rotational Atherectomy in Heavily Calcified Lesions: Evidence From the Largest Cardiac Center in Thailand. Global Heart Vol.17 No.1 (2022). doi:10.5334/GH.1162 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/86255
Title
Clinical Outcomes of Rotational Atherectomy in Heavily Calcified Lesions: Evidence From the Largest Cardiac Center in Thailand
Author's Affiliation
Other Contributor(s)
Abstract
Background: Evidence regarding the clinical outcomes of rotational atherectomy (RA) in middle-income countries is limited. We analyzed the clinical outcomes of patients with heavily calcified coronary lesions who underwent RA-assisted percutaneous coronary intervention (PCI) and explored the risks for developing major adverse cardiovascular and cerebrovascular events (MACCE). Methods: This is a single-center, retrospective cohort analysis that enrolled consecutive patients who underwent RA-assisted PCI at the largest tertiary hospital in Thailand. The primary endpoint is the incidence of MACCE during the first-year follow-up. MACCE consists of cardiac death, ischemic stroke, definite stent thrombosis, target lesion revascularization, and target vessel revascularization. Results: From January 2015 to December 2018, 616 patients (663 lesions) were enrolled. The mean age was 72.8 ± 9.7 years, 292 (47.4%) patients were female and 523 (84.9%) completed one-year follow-up. Drug-eluting stents were deployed in 606 (91.4%) lesions. The RA success rate – defined as when the operator successfully passed the burr across the target lesion – was 99.4% and the angiographic success rate was 94.8%. 130 (21.4%) procedures developed periprocedural complications. The cumulative MACCE rate at 30-days was 1.5% and at 1-year was 6.3%. The in-hospital mortality rate was 1.1% and the cardiac death rate was 1.6%. Independent risk factors for developing MACCE included the use of an intra-aortic balloon pump (hazard ratio [HR] 3.96, 95% confidence interval [CI] 1.54–10.21; P = 0.004), a history coronary artery bypass graft (HR 2.30, 95% CI 1.01–5.25; P = 0.048), and increased serum creatinine (HR 1.16, 95% CI 1.04–1.30; P = 0.008). Conclusions: RA is an effective revascularization technique for heavily calcified lesions. This study demonstrates a high success rate and good short- to intermediate-term results of RA-assisted PCI in middle-income countries which are similar to high-income countries. Nevertheless, the rate of periprocedural complications remains high.